The present study investigates the interaction of aqueous leaf extract of Psidium guajava with muscarinic, serotonergic and adrenergic receptor system using isolated rat ileum, gastric fundus and trachea, respectively. The concentration-dependent contractile response of aqueous leaf extract of Psidium guajava was parallel and rightward of standard agonists, ACh and 5-HT indicating agonistic act...

Type 1 diabetes (T1D) results from the destruction of insulin-secreting pancreatic β cells by autoreactive T cells. Insulin is an essential target of the autoimmune attack. Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecules of nonobese diabetic (NOD) mice, which results in weak agonistic activity of the peptide MHC complex. Here, we describe ...

In this study we used a new call feeding station, which enabled sows to learn that they have access to feed only after an individual acoustic signal was given. We tested whether this call feeding station is able to reduce agonistic interactions between sows and whether effects of call feeding can further be improved by enrichment. A total of 85 gestating sows were kept in a dynamic group in a l...

In this paper, the author presents an alternative approach to ‘design for democracy,’ drawing on the notion of agonistic pluralism. Specifically, the author highlights the differences between politics and the political within agonistic pluralism, and employing examples of contemporary design projects, discusses how these differences can been seen in the objects and practices of design. Through ...

Background OX40, a TNFRSF member, is a co-stimulatory molecule expressed on antigen experienced effector T (Teff) and regulatory T (Treg) cells, including infiltrating cells in mouse and human tumors. Activation of OX40 by agonistic antibodies is hypothesized to promote anti-tumor immunity by enhancing Teff activation and inhibiting Treg mediated suppression. We conducted in vitro and in vivo p...

Sounds are uttered in agonistic contexts by representatives of 30+ families of fishes but this number mainly reflects the scientific expenditure and less so the actual distribution of soundproducing families. Sounds are emitted in numerous contexts: distressful or disturbancesituations, e.g. being attacked or grabbed by predators, competitive feeding, and competition for space and sometimes mat...

The results relating to agonistic behaviour obtained during an exploration of the brain of juvenile herring and lesser black-backed gulls (Larus argentatus andfuscus) with electrical stimulation are reported. As an introduction the normal agonistic behaviour of immature gulls is described. While the flight and aggressive behaviour is largely unritualized the threat behaviour is more stereotyped...