Objective This study analyzed the incidence of Entamoeba gingivalis and Trichomonas tenax in samples of dental biofilm and saliva from patients with gingivitis / periodontitis and in healthy subjects. Methods Biofilm and saliva samples were taken from 20 patients with gingivitis, 22 with periodontitis and 9 healthy individuals. They were spread on sterile Petri dishes, diluted with saline and e...

Recent evidence has determined a phenotypic and functional heterogeneity for macrophage populations. This plasticity of macrophage function has been related to specific properties of subsets (M1 and M2) of these cells in inflammation, adaptive immune responses and resolution of tissue destructive processes. This investigation hypothesized that targeted alterations in the distribution of macroph...

This study aimed to evaluate the possible association between periodontitis and systemic complications in a Brazilian type 1 diabetes population. A multicentre, sectional study was carried out in 28 public clinics located in 20 Brazilian cities. Data from 3,591 patients were obtained (56.0% females, 57.2% Caucasians), with an average age of 21.2 ± 11.7 years and whose mean duration of type 1 di...

Background: There are some discrepancy in association between activity of rheumatoid arthritis (RA) and periodontitis. The aim of this study was to evaluate the periodontal status of outpatients with RA. Methods: The study was conducted in 2013-14 in a rheumatology clinic in Sari, north of Iran on 74 patients with RA. Evaluation of RA disease activity was according to disease activity score 28 ...

BACKGROUND AND OBJECTIVE Aggressive periodontitis is a rare and very severe periodontal disease of early onset, which is closely associated with Porphyromonas.gingivalis (P.g.) infection in the Japanese population. TLR2 encodes Toll-like receptor 2, which plays an important role in the protective response to P.g. infection. We investigated a possible association between TLR2 and aggressive peri...

BACKGROUND: Aggressive periodontitis (AgP) by definition is a group of rare, very destructive forms of periodontitis, usually manifests itself at an early age and shows a marked tendency to aggregate in families. A variety of factors, such as microbial, environmental and behavioral have been suggested as risk factors of Aggressive periodontitis. METHODS: Ten cases with clinical and radiological...

We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Science was conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-...

PURPOSE The aim of this paper is to assess the histopathological changes and the condition of oxidative stress in the saliva of the patients with periodontal disease. MATERIALS AND METHODS We have carried out our research on two groups of patients with periodontitis (a group of 16 patients with stage I periodontitis and a group of 16 patients with stage II periodontitis), who we have compared...

The detection of salivary biomarkers has a potential application in early diagnosis and monitoring of periodontal inflammation. However, searching sensitive salivary biomarkers for periodontitis is still ongoing. Oxidative stress is supposed to play an important role in periodontitis progression and tissue destruction. In this cross-sectional study, we investigated total antioxidant capacity (T...

AIM To determine the presence and location (stroma versus epithelium) of citrullinated proteins in periodontitis tissue as compared to non-periodontitis tissue and synovial tissue of RA patients. MATERIALS & METHODS Periodontitis, healthy periodontal and RA-affected synovial tissue samples were collected in addition to buccal swabs. These samples were stained for the presence of citrullinated...