BACKGROUND The initial systolic blood pressure (SBP) in patients presenting to the hospital with acute heart failure (AHF) informs prognosis, diagnosis, and guides initial treatment. However, over time AHF presentations with elevated SBP appear to have declined. The present study examined whether the frequency of AHF presentations with systolic hypertension (SBP >160 mmHg) declined over a nearl...

BACKGROUND/AIMS Identification of novel biomarkers to identify acute heart failure (AHF) patients at high risk of mortality is an area of unmet clinical need. Recently, we reported that the baseline level of circulating miR-30d was associated with left ventricular remodeling in response to cardiac resynchronization therapy in advanced chronic heart failure patients. However, the role of circula...

In the management of Acute Heart Failure(AHF) patients ,current guidelines suggest to make a prompt clinical assessments that include patient’s congestion and perfusion status evaluation, in order start appropriate treatments. Unfortunately ,so far, an accurate evaluation haemodynamic fluid AHF is only possible using invasive methods ;conseguently there unmeet need for noninvasive technologies ...

Current guidelines for the management of heart failure (HF) divide patients with HF into 2 categories: those with reduced ejection fraction (EF of ≤40%; HFrEF) and those with preserved ejection fraction (>40%; HFpEF). It has been recognized that a subset of patients with HFpEF previously had HFrEF. These patients with recovery or improvement in EF (HFiEF) may be clinically distinct from those w...

AIMS The independent clinical correlates and prognostic impact of QRS prolongation in heart failure (HF) with reduced and preserved ejection fraction (EF) are poorly understood. The rationale for cardiac resynchronization therapy (CRT) in preserved EF is unknown. The aim was to determine the prevalence of, correlates with, and prognostic impact of QRS prolongation in HF with reduced and preserv...

Heart failure (HF) and coronary insufficiency are common amongst surgical and critical care patients. Both are chronic conditions interrupted by acute episodes. HF activates neurohormonal mechanisms that worsen renal and cardiac function. Acute heart failure (AHF) commonly presents with dyspnoea as a consequence of systolic and / or diastolic dysfunction. Goals of treatment are symptom relief, ...

BACKGROUND The oral vasopressin-2 receptor antagonist tolvaptan causes aquaresis in patients with volume overload, potentially facilitating decongestion and improving the clinical course of patients with acute heart failure (AHF). OBJECTIVES The TACTICS-HF (Targeting Acute Congestion with Tolvaptan in Congestive Heart Failure) study was conducted to address the acute use of tolvaptan to impro...

Acute heart failure (AHF) is characterized by high morbidity and mortality and high costs. Although the treatment of AHF has not changed substantially in recent decades, it is becoming clear that treatment strategies for AHF need to address both the immediate hemodynamic abnormalities giving rise to congestion as well as prevent organ damage that can influence long-term prognosis. Serelaxin, th...

BACKGROUND To evaluate diagnostic and long-term prognostic values of hFABP compared to NT-proBNP and troponin I (TnI) in patients presenting to the emergency department (ED) suspected of acute heart failure (AHF). METHODS 401 patients with acute dyspnea or peripheral edema, 122 suffering from AHF, were prospectively enrolled and followed up to 5 years. hFABP combined with NT-proBNP versus NT-...

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): British Heart Foundation HRUK Background. Four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR) imaging provides quantification intra-cavity left ventricular (LV) kinetic energy (KE) parameters in three dimensions. Myocardial infarction (MI) is known to cause acute alterations intra-cardiac ...