نتایج جستجو برای: aj
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Epithelial integrity is vitally important, and its deregulation causes early stage cancer. De novo formation of an adherens junction (AJ) between single epithelial cells requires coordinated, spatial actin dynamics, but the mechanisms steering nascent actin polymerization for cell-cell adhesion initiation are not well understood. Here we investigated real-time actin assembly during daughter cel...
Increased vascular permeability is an inciting event in many vascular complications including diabetic retinopathy. We have previously reported that pigment epithelium-derived factor (PEDF) is able to inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis through a novel γ-secretase-dependent pathway. In this study, we asked whether inhibition of VEGF-induced permeability by PED...
Endothelial barrier function is regulated by adherens junctions (AJs) and caveolae-mediated transcellular pathways. The opening of AJs that is observed in caveolin-1(-/-) (Cav-1(-/-)) endothelium suggests that Cav-1 is necessary for AJ assembly or maintenance. Here, using endothelial cells isolated from Cav-1(-/-) mice, we show that Cav-1 deficiency induced the activation of endothelial nitric ...
Zika virus (ZIKV) directly infects neural progenitors and impairs their proliferation. How ZIKV interacts with the host molecular machinery to impact neurogenesis in vivo is not well understood. Here, by systematically introducing individual proteins encoded by ZIKV into the embryonic mouse cortex, we show that expression of ZIKV-NS2A, but not Dengue virus (DENV)-NS2A, leads to reduced prolifer...
k=1 |ak| , in which C = (cj,k) and the parameter p are assumed fixed (p > 1), and the estimate is to hold for all complex sequences a. The lp operator norm of C is then defined as the p-th root of the smallest value of the constant U : ||C||p,p = U 1 p . Hardy’s inequality thus asserts that the Cesáro matrix operator C, given by cj,k = 1/j, k ≤ j and 0 otherwise, is bounded on lp and has norm ≤...
We prove a result which implies that, for any real numbers a and b satisfying 0 ≤ a ≤ b ≤ 1, there exists an infinite sequence of positive integers A with lower density a and upper density b such that the sets A and N \ A contain no infinite arithmetic and geometric progressions. Furthermore, for any m ≥ 2 and any positive numbers a1, . . . , am satisfying a1 + · · · + am = 1, we give an explic...
Motivated by a question of Sárközy, we study the gaps in the product sequence B = A · A = {b1 < b2 < · · · } of all products aiaj with ai, aj ∈ A when A has upper Banach density α > 0. We prove that there are infinitely many gaps bn+1 − bn ¿ α−3 and that for t ≥ 2 there are infinitely many t-gaps bn+t − bn ¿ t2α−4. Furthermore we prove that these estimates are best possible. We also discuss a r...
There is compelling evidence that genetic factors play an important role in prostate cancer, but no unequivocally disease causing mutations in prostate cancer susceptibility genes have been identified. In 2002, Carpten et al reported that variants in the gene RNASEL were present in some multiple case prostate cancer families. RNASEL maps to the region of chromosome 1q that has been linked to pr...
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