The influence of assay method on single dose cyclosporine (CsA) pharmacokinetics was studied in nine dogs receiving either i.v. or oral CsA. Samples were drawn from hepatic, portal, and systemic veins at various times after the dose and CsA levels were determined by radioimmunoassay (RIA) and high-performance liquid chromatography (HPLC). Blood concentration-time data were analyzed by nonlinear...

This paper presents two modifications to the eigenphases method to increase its accuracy. In the first modification, called Local Spatial Domain Eigenphases (LSDE), the face image is first segmented into blocks of N × N pixels, whose magnitudes are normalized. These blocks are then concatenated before the phase spectrum estimation, and finally Principal Component Analysis (PCA) is used for dime...

CD22/3 is a B cell-restricted phosphoprotein expressed on the surface of mature resting B cells. It mediates interactions with other cells partly or exclusively via recognition of ot2-6-1inked sialic acids on glycoconjugates. The sialylated N-linked oligosaccharides recognized best by CD22/~ are common to many glycoproteins, suggesting that additional regulatory mechanisms may exist. Since the ...

Ajit Varki Glycobiology Research and Training Center, Dept of Medicine and Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. The sialic acid (Sia)-binding Ig-like lectins (Siglecs)1 were discovered through independent studies on a macrophage lectin-like adhesion molecule named sialoadhesin2 and a B-cell restricted member of the Ig superfamily (IgSF), CD22 (Ref. 3). Bo...

Michael Eisen, University of California, Berkeley Identifying the genomic regions bound by sequence specific regulatory factors is central both to deciphering the complex DNA cis-regulatory code that controls transcription in metazoans and to determining the range of genes that shape animal morphogenesis. We have used whole-genome tiling arrays to map sequences bound in Drosophila melanogaster ...

Less than a decade ago, the cloning of three seemingly disparate vascular cell surface molecules uncovered the selectin family of receptors that are now known to mediate critical cell-cell interactions in processes such as leukocyte trafficking, thrombosis, acute and chronic inflammation, and ischemia-reperfusion injury (1–15). L-, E-, and P-selectin are type-1 membrane glycoproteins sharing a ...

Symposium in Brazil I n January, several hundred nuclear medicine specialists from around the world came together in Porto Alegre, Brazil, for the International Atomic Energy Agency (IAEA) International Symposium on Nuclear Oncology, for which the SNM was a cosponsor and contributor of expert resources and logistic support. Held from January 19 through 23 in cooperation with the government of B...

In numerous real world applications, from sensor networks to computer vision to natural text processing, one needs to reason about the system in question in the face of uncertainty. A key problem in all those settings is to compute the probability distribution over the variables of interest (the query) given the observed values of other random variables (the evidence). Probabilistic graphical m...

In this study, the oil recovery potential of Smart Water in the Danish sector of the North Sea chalk reservoirs was investigated. A series of flooding experiments were conducted at reservoir conditions, and a spontaneous imbibition test was carried out at reservoir temperature. Reservoir cores were used along with crude oil samples from the North Sea and representative synthetic formation water...