Increased serum bile salt levels have been associated to a single-nucleotide polymorphism in the bile salt export pump (BSEP; ABCB11) in several acquired cholestatic liver diseases but there is little evidence in alcoholic liver disease (ALD). Furthermore, a crosstalk between vitamin D and bile acid synthesis has recently been discovered. Whether this crosstalk has an influence on the course of...

Chronic liver disease with cirrhosis is the 12th leading cause of death in the United States, and alcoholic liver disease accounts for approximately half of all cirrhosis deaths. Chronic alcohol consumption is associated with intestinal bacterial dysbiosis, yet we understand little about the contribution of intestinal fungi, or mycobiota, to alcoholic liver disease. Here we have demonstrated th...

Obesity is commonly associated with non-alcoholic fatty liver disease and a significant cause of chronic cirrhosis. Some patients undergoing bariatric surgery suffer from cirrhosis the liver. Currently, there lack consensus on management these safety efficacy in this group. This review aims to update our previously published systematic same topic. A total 21 studies reporting experience were in...

Enhanced serum IgA concentrations are common in alcoholic liver cirrhosis, but functional differences between IgA subclasses and their relation with interleukin-6 (IL-6) have not been described. Distinct immunoregulatory mechanisms may exist that selectively affect one subclass. This possibility prompted us to investigate the distribution of IgA1 and IgA2 subclasses in the serum of 25 heavy alc...

The Republic of Korea (hereafter Korea) is one of the countries with high incidence of liver cancer and there is great difference in incidence of liver cancer between male and female. We investigated the sex-specific trends of three major risk factors of liver cancer, which are hepatitis B virus(HBV) infection, hepatitis C virus(HCV) infection, and alcoholic liver cirrhosis. The incidence of li...

Alcohol remains one of the most abused substances worldwide. Studies over years have attributed chronic alcoholism as a major risk factor to liver cirrhosis. Patients with cirrhosis develop portal hypertension which put them at higher having esophageal varices and other associated complications. The authors present case alcoholic male individual who developed along less reported complications l...

UNLABELLED The ability of endogenous IL-10 to modulate inflammatory response and to limit hepatotoxicity has been shown in several models of liver injury. AIMS The objectives of this study were to evaluate the relationship between liver disease and the balance between pro and anti-inflammatory cytokines in acute alcoholic hepatitis. METHODS Twenty-five patients with pure steatosis, 17 with ...

Clinical features of 52 patients with alcoholic hepatic diseases were described. Of these patients 27 had alcoholic hepatic cirrhosis. As compared with hepatic cirrhosis due to icteric viral hepatitis, vascular spider, ascites and edema were found more frequently in alcoholic cirrhosis. Hepatic biopsy showed preponderance of cirrhotic changes of postnecrotic type. Twenty-five patients had alcoh...