The occurrence of non-alcoholic fatty liver disease has exponentially increased worldwide. A considerable majority cases advance to non-Alcoholic Steatohepatitis in the nonexistence therapeutic measures, which increases morbidity and death. Because initial phases illness are frequently clinically unapparent, identification rests on biochemical radiographic studies. Concentrated life modificatio...

Non-alcoholic steatohepatitis (NASH) is a clinicopathological entity characterized by histological features resembling alcoholic liver disease that occurs in persons who consume little or no alcohol. NASH is a part of the spectrum of non-alcoholic fatty liver disease (NAFLD) and is defined by of the presence of ballooning (zone 3) hepatocellular injury and inflammation in addition to steatosis....

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the hepatic manifestations of the metabolic syndrome. Since the prevalence of obesity and consequently of the metabolic syndrome is steadily increasing, the different types of NAFLD are nowadays the most common cause of liver injury in North America. The development of NASH and fatty liver cirrhosis occurs af...

In the last three decades the prevalence of non-alcoholic fatty liver disease has markedly increased. Results from epidemiologic studies indicate that not only a general overnutrition but rather a diet rich in sugar, fat and cholesterol (= Western style diet) maybe a risk factor for the development of non-alcoholic fatty liver disease. Concerning liver diseases, it is known that Deleted in mali...

CONTEXT Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, with 5-10% of liver having extra fat. Increase in its prevalence in all age groups is linked with obesity and Type II diabetes. The treatment of NAFLD remains controversial. A growing body of evidence suggests a relation between overgrowth of gut microbiota with NAFLD and non-alcoholic steatohepatitis (NASH). The obje...

results the relative expression of mtdna copy number was 3.7 fold higher in nafld patients than healthy controls (p < 0.0001). the results remained significant after adjustment for age, bmi, and gender (p = 0.02). in addition, the mtdna copy number was 4.3 (p < 0.0001) and 3.2-fold (p < 0.0001) higher in nonalcoholic fatty liver (nafl) and non-alcoholic steatohepatitis (nash) patients than heal...

This comment discusses the study by Videla and colleagues in this issue of Clinical Science in which they have analysed surgical liver biopsies from obese patients with non-alcoholic fatty liver disease and demonstrate that fatty liver is associated with a state of oxidative stress and a decreased antioxidant activity. As the disease progresses to steatohepatitis, the defect in antioxidant syst...