AIMS Hyperaldosteronism is associated with an increased prevalence of atrial fibrillation (AF). However, it is unclear whether this is the consequence of altered haemodynamics or a direct aldosterone effect. It was the aim of the study to demonstrate load-independent effects of aldosterone on atrial structure and electrophysiology. METHODS Osmotic mini-pumps delivering 1.5 µg/h aldosterone we...

1. ALDO-DHF STUDY – A NEW INDICATION FOR AN OLD DRUG? Results of the ALDOsterone receptor blockade in Diastolic Heart Failure (ALDO-DHF) were recently presented at the European Society of Cardiology (ESC) meeting in Munich [1]. The multicenter, double-blind randomized, placebo-controlled phase IIb mechanistic study was conducted to test the hypothesis that 12 months treatment with spironolacton...

We give an introduction to the theory of determinantal ideals and rings, their Gröbner bases, initial ideals and algebras, respectively. The approach is based on the straightening law and the Knuth-Robinson-Schensted correspondence. The article contains a section treating the basic results about the passage to initial ideals and algebras. Let K be a field and X an m×n matrix of indeterminates o...

N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) inhibits not only hematopoietic cell proliferation but also fibroblast proliferation and collagen synthesis in vitro. Ac-SDKP also prevents collagen deposition and cell proliferation in the left ventricle (LV) in rats with renovascular hypertension (renin dependent). However, it is not clear whether Ac-SDKP has similar effects in a model of renin-...

*Both authors contributed equally. Dept. Biochemical Sciences "A. Rossi Fanelli", CNR Institute of Molecular Biology and Pathology, and Istituto Pasteur-Fondazione Cenci Bolognetti, University "La Sapienza", Piazzale Aldo Moro 5, 00185 Rome, Italy Molecular and Cell Biology and Molecular Oncology Laboratory, IDI-IRCCS, via Monti di Creta 104, 00167 Rome, Italy Dept. Molecular Biology, Universit...

Matteo Serafino, Andrea Gabrielli, 3, 4 Guido Caldarelli, 2, 4, 5 and Giulio Cimini 2, ∗ Dipartimento di Fisica, Università “Sapienza”, Piazzale Aldo Moro 5, 00185 Rome Italy Istituto dei Sistemi Complessi (ISC)-CNR UoS Università “Sapienza”, Piazzale Aldo Moro 5, 00185 Rome Italy IMT School for Advanced Studies, Piazza S.Francesco 19, 55100 Lucca Italy London Institute for Mathematical Science...

Nicolò Spagnolo,1,2 Fabio Sciarrino,1,3 and Francesco De Martini1,4,* 1Dipartimento di Fisica, Sapienza Università di Roma, piazzale Aldo Moro 5, I-00185 Roma, Italy 2Consorzio Interuniversitario per le Scienze Fisiche della Materia, piazzale Aldo Moro 5, I-00185 Roma, Italy 3Istituto Nazionale di Ottica, largo Fermi 6, I-50125 Firenze, Italy 4Accademia Nazionale dei Lincei, via della Lungara 1...