BACKGROUND Available alfentanil pharmacokinetic (PK) sets for target-controlled infusion (TCI) were derived from populations with normal BMI. The performance and accuracy of the models devised by Maitre and colleagues and Scott and colleagues were evaluated in a population including morbidly obese patients. METHODS Alfentanil TCI using Maitre and colleagues' model was administered to 10 obese...

BACKGROUND Sufentanil and alfentanil have pharmacokinetic and dynamic properties which make them favourable substances for total intravenous anesthesia (TIVA) in combination with propofol. OBJECTIVES We planned to compare two clinical protocols for TIVA with propofol, and either sufentanil or alfentanil in regards to postoperative pain, hemodynamic stability during the case and time for emerg...

OBJECTIVE We aimed to evaluate the depth of anaesthesia, perioperative haemodynamics, postoperative pain scores, analgesic consumption in patients receiving remifentanil- or alfentanil-based total intravenous anaesthesia for single-level lumbar discectomy. METHODS Seventy patients undergoing discectomy were enrolled in the study. Patients were intravenously administered an initial bolus dose ...

BACKGROUND Although CT colonography is a less invasive alternative for colonoscopy for the detection of colorectal polyps and cancer, procedural pain is common. In several studies, CT colonography pain and burden is higher than in colonoscopy. Apart from discomfort, anxiety and its related stress-induced peri- procedural side effects, this may influence the adherence for CT colonography as a po...

BACKGROUND Extensive pulmonary uptake of lipophilic basic amines, such as fentanyl, attenuates early blood drug concentrations after rapid intravenous administration. The basis of this phenomenon is poorly understood. The authors tested the hypothesis that fentanyl uptake into cultured human lung microvascular endothelial (HMVE-L) cells occurs by facilitated uptake in addition to passive diffus...

patients and methods this was a randomized double-blinded study conducted on 90 patients (18-65 years old, asa i, ii), who needed intubation following trauma. the patients were randomly divided into three groups, group i, group ii and group iii, who have received alfentanil, fentanyl and sufentanil, respectively. heart rate, blood pressure, saturation of peripheral oxygen and end-tidal carbon d...

BACKGROUND There is increasing interest in balanced propofol sedation (BPS) titrated to moderate sedation (conscious sedation) for endoscopic procedures. However, few controlled studies on BPS targeted to deep sedation for diagnostic endoscopy were found. Alfentanil, a rapid and short-acting synthetic analog of fentanyl, appears to offer clinically significant advantages over fentanyl during ou...

My objective is to analyze the efficiency of remifentanil-propofol and alfentanil-propofol combinations for laryngoscopic endotracheal intubation in the absence of muscle relaxants. This analysis reviews the work by Imani et al. (1). Muscle relaxants are frequently used to facilitate endotracheal intubation during anesthesia induction. However, the administration of short-acting depolarizing mu...