Film dosage forms (FDs) containing valsartan (VST), a popular antihypertensive drug, were prepared using a casting method with sodium alginate and other polysaccharides as the film base. Drug dissolution profiles of the FDs were investigated in limited medium. The FDs were 170-200 μm thick and were easy to handle. All FDs immediately swelled and disintegrated in the medium. About 23% of the VST...

BACKGROUND Chlorpheniramine maleate (CM) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. OBJECTIVES The purpose of this research was to mask the bitter taste of CM by formulating microspheres of the taste-masked drug. MAT...

The aim of the present study was to develop novel Mycobacterium bovis bacille Calmette-Guérin (BCG)-loaded polymeric microparticles with optimized particle surface characteristics and biocompatibility, so that whole live attenuated bacteria could be further used for pre-exposure vaccination against Mycobacterium tuberculosis by the intranasal route. BCG was encapsulated in chitosan and alginate...

Immediately following spinal cord injury, further injury can occur through several secondary injury cascades. As a consequence of cell lysis, an increase in extracellular Ca(2+) results in additional neuronal loss by inducing apoptosis. Thus, hydrogels that reduce extracellular Ca(2+) concentration may reduce secondary injury severity. The goal of this study was to develop composite hydrogels c...

Chitosan hydrogels are of considerable interest in synthetic biomimetic mineralisation strategies due to their favourable characteristics such as the presentation of a large surface area for crystal nucleation within a structured yet responsive scaffold. Chitosan hydrogels were prepared and subsequently calcium carbonate mineralisation was initiated using a method which combines alternate soaki...

Plasters and renders used in historic monuments are vulnerable to degradation caused by salt weathering. Crystallisation inhibitors (molecules/ions that alter crystallisation) mixed into mortars have shown promising results mitigating damage inhibiting crystallisation, promoting transport the evaporating surface, modifying crystal habit. However, past research suggests easily leach out from mor...

Supercritically dried aerogels of several polysaccharides (chitin, chitosan, alginate, alginic acid, kcarrageenan, andagar) havebeencharacterisedbyphysisorptionofN2. Surface areas ashighas570m g have been measured. The nature of the functional groups of the polysaccharide significantly influences the adsorption of N2 on the surface of the aerogel. The net enthalpy of adsorption increases with t...

Mục tiêu: Đánh giá tác dụng cải thiện rối loạn chuyển hóa Lipid máu của nano Alginate/Chitosan/ Lovastatin trên chuột cống trắng béo phì bằng thức ăn cao năng giàu chất béo. Đối tượng và phương pháp: 72 đực ở hai nhóm chế độ thường (n = 36) 36). Sau giai đoạn gây mô hình 7 tuần được chia đều ngẫu nhiên làm 6 gồm: 1) thường-uống nước muối (C-NaCl), 2) liều 4 mg/kg (C-Lovastatin), 3) tổ hợp Algin...

Background: Pancreatic islet transplantation is one of the most promising strategies for treating patients with type I diabetes mellitus.Objective: We aimed to assess the immunoisolation properties of the multilayer encapsulated islets using alginate-chitosan-PEG for immunoprotection and insulin secretion from the encapsulated islets induced under differe...

the purpose of the research was to formulate microspheres of acyclovir (acv) using mucoadhesive polymers, sodium alginate and chitosan. calcium chloride was used as the ionotropic gelling agent. sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...