INTRODUCTION Sepsis-induced acute lung injury (ALI) has been reported to have a higher case fatality rate than other causes of ALI. However, differences in the severity of illness in septic vs. non-septic ALI patients might explain this finding. METHODS 520 patients enrolled in the Improving Care of ALI Patients Study (ICAP) were prospectively characterized as having sepsis or non sepsis-indu...

We present an estimation-theoretic approach to curve evolution for the Mumford-Shah problem. By viewing an active contour as the set of discontinuities in the Mumford-Shah problem, we may use the corresponding functional to determine gradient descent evolution equations to deform the active contour. In each gradient descent step, we solve a corresponding optimal estimation problem, connecting t...

Current gene therapy strategies using adenoviral vectors to target the lung or liver have been complicated by an acute inflammatory response that can result in loss of transgene expression as well as tissue injury and necrosis. Skeletal muscle comprises 4 0 % oftotal body weight; it possesses a high density, accessible capillary network that is resistant to injury and thus m a y be a logical ta...

This paper develops an aggregate income mobility measure based on income transition matrices. The proposed measure satisfies certain desirable properties and captures different facets of mobility. It is additively decomposable into upward and downward mobility components which help us in understanding the nature of mobility. The proposed measure is also additively decomposable into income sub-g...

A. Hughes, L. Staveley-Smith, S. Kim, M. Wolleben, M. Filipović 1 Centre for Supercomputing and Astrophysics, Swinburne University of Technology, Hawthorn VIC 3122, Australia 2 CSIRO Australia Telescope National Facility, PO Box 76, Epping NSW 1710, Australia 3 School of Physics M013, University of Western Australia, Crawley WA 6009, Australia 4 Department of Astronomy and Space Science, Sejong...

Receptor for advanced glycation end-products (RAGE) is a marker of alveolar type I cells and is elevated in the pulmonary edema fluid of patients with acute lung injury (ALI). We tested the hypothesis that RAGE in the bronchoalveolar lavage (BAL) would be elevated in experimental models of direct ALI characterized by alveolar epithelial cell injury. We developed ELISA measurements for RAGE and ...