Valence stabilization of polyvalent ions in acidic solutions during gamma irradiation is an important issue in nuclear aqueous chemical technology. Radiolysis and self irradiation problems encountered during chemical reprocessing of nuclear fuel or during chemical separation of transuranium elements or fission products are extremely important. Consequently studies on valence stabilization of po...

A series of carbocyclic analogues of netropsin were synthesized and evaluated for their capacity to inhibit human topoisomerases I and II in vitro. The compounds are oligopeptides containing 1,4-di- and 1,2,5-trisubstituted benzene rings and unsubstituted N-terminal NH2 groups. Compounds 4-7 consist of two netropsin-like units linked by aliphatic (tetra- and hexamethylene) chains. In the topois...

Stars in the late stages of evolution are able to synthesize complex organic compounds with aromatic and aliphatic structures over very short time scales. These compounds are ejected into the interstellar medium and distributed throughout the Galaxy. The structures of these compounds are similar to the insoluble organic matter found in meteorites. In this paper, we discuss to what extent stella...

A phenylethanoid glycoside (ilicifolioside A) and an aliphatic alcohol glycoside (ilicifolioside B), have been isolated from the aerial parts of Acanthus ilicifolius, together with eight known compounds. Their structures were determined from spectroscopic analyses.

The synthesis of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid was studied. The structures of synthesized compounds were proved by micro-analyses, IR- and 1H NMR data. Values of acute p.o. and i.p. toxicity in mice show lower toxicity compared to caffeine. Declines in spontaneous locomotor activity support the idea of depressive CNS activity of the compounds. Two compo...

The present communication deals with the local anesthetic activity and toxicity of 16 basic alkyl esters of substituted pyrrolidine dicarboxylic acids.t In an accompanying article5 the intestinal, uterine, and depressor activity of these compounds is presented. Twelve of the compounds were 2, 5-di-(3-diethylaminoethyl) esters and 3 were 2, 5-di-(y-diethylaminopropyl) esters. One was 2-(Zdiethyl...

A highly sensitive fluorimetric procedure based on alkylation of nicotinamide is described for the determination of aliphatic epoxides. Subsequent reaction of the resulting N-alkylnicotinamides with a ketone in basic medium yields strongly fluorescent products after final acidification. Sensitivity of the assay is in the picomole range with good reproducibility. The alkylation reaction proceeds...