Human heart Na 1 channels were expressed transiently in both mammalian cells and Xenopus oocytes, and Na 1 currents measured using 150 mM intracellular Na 1 . The kinetics of decaying outward Na 1 current in response to 1-s depolarizations in the F1485Q mutant depends on the predominant cation in the extracellular solution, suggesting an effect on slow inactivation. The decay rate is lower for ...

In a previous communication (1) it was shown that data obtained from transference experiments with alkali solutions of casein could be best interpreted on the assumption that the carriers of the current are alkali metal cations and casein anions. In the present studies on the transport numbers of solutions of casein with the alkali earth elements, the data appear to indicate that part of the me...

Monte Carlo simulations were employed to gain insight on HCN adsorption mechanism on LTA zeolites with different alkali metal cations, Li, Na, and K. Adsorption isotherms were calculated at four different temperatures at and above the normal boiling point of HCN. Results show that adsorption capacity depends on the type of the extraframework cation and Li-LTA showed the highest HCN adsorption c...

Complexes of 18-crown-6 with alkali-metal cations (Na', K', and Rb'), urea, and the uncomplexed crown ether were studied in V ~ C U O with the molecular dynamics method. Conformational data from these calculations (simulation times in the range from 6-15 ns) was compared with information from the Cambridge Structural Database. Despite the differences in condition between the simulations and the...

Ions play a modulatory role in many proteins. Kainate receptors, members of the ionotropic glutamate receptor family, require both monovalent anions and cations in the extracellular milieu for normal channel activity. Molecular dynamics simulations and extensive relative binding free energy calculations using thermodynamic integration were performed to elucidate the rank order of binding of mon...

Ultraviolet photodepletion spectra of dibenzo-18-crown-6-ether complexes with alkali metal cations (M(+)-DB18C6, M = Cs, Rb, K, Na, and Li) were obtained in the gas phase using electrospray ionization quadrupole ion-trap reflectron time-of-flight mass spectrometry. The spectra exhibited a few distinct absorption bands in the wavenumber region of 35 450-37 800 cm(-1). The lowest-energy band was ...

NaSm(PO(3))(4) has been prepared by solid state reactions. It belongs to type II of the structural family of M(I)Ln(III)(PO(3))(4) compounds (M(I) = alkali metal and Ln(III) = rare earth metal) and is composed of (∞)(PO(3))(n)](n-) polyphosphate chains with a repeating unit of four PO(4) tetra-hedra. The chains extend parallel to [100] and share O atoms with irregular SmO(8) polyhedra, forming ...

Structural, magnetic, and transport properties of ðLa1 xNdxÞ0:8Na0:2MnO3 ð0pxp1Þ are studied. The system exhibits a rhombohedrally distorted perovskite structure for xp0:2 and it converts to an orthorhombic structure for xX0:4: Re-entrant ferromagnetic-type charge ordering transitions are observed in the narrow bandwidth samples ðxX0:8Þ: For T > 77 K; the compounds show metal to insulator trans...

1. The relative permeability of the native P2X receptor channel to monovalent and divalent inorganic and organic cations was determined from reversal potential measurements of ATP-evoked currents in parasympathetic neurones dissociated from rat submandibular ganglia using the dialysed whole-cell patch clamp technique. 2. The P2X receptor-channel exhibited weak selectivity among the alkali metal...