نتایج جستجو برای: allogeneic stem cell transplantation
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background: thalassemia is probably the most common single gene disorder causing a major public health problem in the world. currently, allogenic hematopoietic stem cell transplantation (hsct) is the only curative therapy for thalassemia. one major limitation of hsct is the lack of hla-identical sibling donors, so attention has turned to finding phenotypically matched unrelated donors. patients...
BACKGROUND Allogeneic stem cell transplantation is associated with a powerful 'graft-versus-leukemia' effect that is generally considered to result from an alloreactive T-cell immune response. However, disease remission can also be observed after syngeneic transplantation and we investigated whether a T-cell immune response to cancer-testis antigens can be detected in patients in the post-trans...
Myelodysplastic syndromes are clonal disorders with morphological dysplasia, a variable degree of cytopenia and risk transformation to acute myeloid leukemia. Prognosis is very defined by blast count, cytopenia, cytogenetics more recently somatic mutations, IPSS or revised score being the most widely used assess disease risk. HSCT remains only curative treatment date, high-risk patients obtaini...
Peripheral neuropathy is associated with chronic debilitating pain and difficult to treat. In this regard, the development of cell therapy neuropathic using adipose-derived mesenchymal stem cells (MSCs) seems be relevant. The work was devoted study impact allogeneic MSC transplantation on nociceptive reactions in response mechanical thermal stimuli gait parameters rats sciatic nerve injury. It ...
We present a case of life-threatening Epstein-Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) with severe hepatitis that was successfully treated by allogeneic stem cell transplantation from an unrelated donor. A 26-year-old woman was admitted to hospital with a high fever and liver dysfunction. Laboratory tests, including bone marrow aspiration, revealed severe HLH that oc...
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