INTORDUCTION Methyldopa is (2S)-2-amino-3-(3, 4dihydroxyphenyl)-2-methylpropanoic acid (figure1a). Hydrochlorothiazide is 6-chloro-1, 1-dioxo-3,4dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide (figure1b). Methyldopa and Hydrochlorothiazide are official in Indian Pharmacopoeia and U.S. Pharmacopoeia, but there is no official method for the combination. Both drugs in combination of tablet dosage ...

The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respectively) were administered systemically, individually and in combination. None of...

Several drugs used for standard antihypertensive therapy may also interact with the lipoprotein metabolism. The following has been observed after 1 to 12 months of treatment. Various thiazide-type diuretics may significantly increase the potentially atherogenic serum low-density-lipoprotein cholesterol (LDL-C) and/or very-LDL-C-fractions, while the antiatherogenic high-density-lipoprotein chole...

The metabolic fate of the tyrosine hydroxylase inhibitor, alpha-methyl-para-tyrosine (alpha-MPT), was studied after oral administration of single and multiple doses to patients with pheochromocytoma and essential hypertension. No major urinary excretion product was found other than the drug itself, which accounted for 44-88% of the fate of single or repeated oral doses. Though less than 1% of t...