Introduction Transcranial magnetic stimulation (TMS) is a non-invasive intervention that holds promise for improving cognitive function in individuals with Alzheimer's disease (AD). However, the effectiveness of this therapy and optimal TMS parameters has not reached consensus. The purpose meta-analysis was to systematically discern different components protocols on improvement patients mild im...

BACKGROUND Alzheimers disease (AD) is a devastative neurodegenerative disorder. Lack of substantial animal model that can unravel molecular underpinnings has been a major lacuna which limited the understanding of the etiology of the disease in turn limiting the employment of potential therapeutic strategies to combat the disease for a few decades. Our studies for the first time provided substan...

Parkinson Disease (PD) is a degenerative disease of the extrapyramidal motor system. The formations midbrain are affected and expressed in 1. Tremor, 2. Hypokinesia, 3. Muscle rigidity, 4. Postural instability. Alzheimer's (AD) progressive form senile dementia, leading to complete loss cognitive abilities, developing mainly after 60-65 years age. With these diseases, large number brain structur...

We introduce a novel approach for the automatic classification of FDG-PET scans of subjects with Alzheimers Disease (AD) and Frontotemporal dementia (FTD). Unlike previous work in the literature which focuses on principal component analysis and predefined regions of interest, we propose the use of decision tree learning combined with empirically determined regions of interest as attributes. The...

Alzheimers disease (AD) is the most common cause of dementia. Although the underlying pathology is still not completely understood, several diagnostic methods are available. Frequently, the most accurate methods are also the most invasive. The present work investigates the diagnostic potential of Pulsed Arterial Spin Labeling (PASL) for AD: a non-invasive, MRI-based technique for the quantifica...

OBJECTIVES Alzheimer's disease is an age-related neurodegenerative disease and a synaptic function defect disease, the clinical symptoms are mainly progressive cognitive impairment, affecting patient's social function. Aim of this report was to investigate the effect of topiramate on apoptosis-related protein expression (Bcl-2, Survivin, Fas, Bax and Caspase-3) in the hippocampus of a rat model...

Acetylcholine (Ach) and N-methyl-D-aspartate (NMDA) have been two major therapeutic targets of Alzheimer’s disease (AD) for decade. However, truly effective remedy for AD has not been successfully developed. We previously transplanted neurons derived from human induced pluripotent stem (hiPS) cells into the hippocampus of human amyloid precursor protein transgenic AD model mice. The cell transp...