نتایج جستجو برای: amorph urate
تعداد نتایج: 4153 فیلتر نتایج به سال:
The release of human platelet constituents by the etiologic agent of gout, the monosodium urate crystal, is described here. In suspensions of washed platelets, response to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of lactic dehydrogenase or beta-glucuronidase. A lytic phase involved the slower loss of ...
Feline Urate Urolithiasis After CaOx and struvite containing uroliths, urate uroliths appear to be the third most common mineral type submitted to our laboratory from cats. Although fluctuations in the percentage of struvite and CaOx containing uroliths have occurred over the past 25 years, the same does not appear to be true of urate uroliths. Therefore, it appears that whatever changes occurr...
On the basis of differential and density gradient centrifugation studies, the site of the uric acid degrading enzymes, urate oxidase and allantoinase, in amphibia was previously assigned to the hepatic peroxisomes. Using specific antibodies against frog urate oxidase and allantoinase, we have undertaken an immunocytochemical study of the localization of these two proteins in frog liver and kidn...
DANTZLER, WILLIAM H. Churacteristics of urate transport by isolated pcrjused snake proximal renal tubules. Am. J. Physiol. 224(2) : 445-453. 1973.-Urate transport was studied in isolated, perfused snake ( Thamnophis spp. ) p roximal renal tubules in vitro. Secretion of urate from bath to tubule lumen occurred against a concentration gradient at flow rates varying from 0.08 to 7 nl/min. Urate tu...
In many crustaceans, changing concentrations of several low molecular weight compounds modulates hemocyanin oxygen binding, resulting in lower or higher oxygen affinities of the pigment. The nonphysiological effector caffeine and the physiological modulator urate, the latter accumulating in the hemolymph of the lobster Homarus vulgaris during hypoxia, increase hemocyanin oxygen affinity and dec...
BACKGROUND Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. OBJECTIVES Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), ischemic stroke, and heart failure (HF). ...
BACKGROUND Rasburicase (Fasturtec® or Elitek®, Sanofi-Aventis), the recombinant form of urate oxidase from Aspergillus flavus, is a therapeutic enzyme used to prevent or decrease the high levels of uric acid in blood that can occur as a result of chemotherapy. It is produced by Sanofi-Aventis and currently purified via several standard steps of chromatography. This work explores the feasibility...
OBJECTIVES The aims of this study were to establish whether, in patients with gout, MPO is released from neutrophils and urate is oxidized to allantoin and if these effects are attenuated by allopurinol. METHODS MPO, urate, allantoin and oxypurinol were measured in plasma from 54 patients with gout and 27 healthy controls. Twenty-three patients had acute gout, 13 of whom were receiving allopu...
BACKGROUND The risk of Parkinson disease (PD) and its rate of progression may decline with increasing concentration of blood urate, a major antioxidant. OBJECTIVE To determine whether serum and cerebrospinal fluid concentrations of urate predict clinical progression in patients with PD. DESIGN, SETTING, AND PARTICIPANTS Eight hundred subjects with early PD enrolled in the Deprenyl and Tocop...
The specific effects of L-lactate and urate on oxygen binding by the haemocyanin of the lobster Homarus vulgaris were investigated. Increasing concentrations of L-lactate were found to increase haemocyanin oxygen-affinity. The relationship between the oxygen affinity (logP50) and [L-lactate] expressed as (Alog/5())(Alog[L-lactate])"' was -0.11 at L-lactate concentrations between 0.3 and 1 Immoi...
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