نتایج جستجو برای: amphetamine anti
تعداد نتایج: 368083 فیلتر نتایج به سال:
Opioid antagonists attenuate behavioral effects of amphetamine and amphetamine-induced increases in extracellular dopamine levels in nucleus accumbens and striatum of rats but do not alter those effects of cocaine. This study was performed to determine 1) if the effect of opioid antagonists on the dopamine response to amphetamine is mediated in either the terminal or cell body region of the nig...
The present study investigated whether the rotation rate induced by amphetamine in 6-OHDA-lesioned rats was predictive of development of L-DOPA-induced dyskinesia (LID) and success of the lesion procedure in our experimental settings. We collected data from 312 6-OHDA-lesioned rats (from different sets of experiments). Rats were subjected to the amphetamine-induced rotation test (2.5mg/kg) and ...
This study aimed to replicate a previous study which showed that endogenous opioid release, following an oral dose of amphetamine, can be detected in the living human brain using [11C]carfentanil positron emission tomography (PET) imaging. Nine healthy volunteers underwent two [11C]carfentanil PET scans, one before and one 3 h following oral amphetamine administration (0.5 mg/kg). Regional chan...
The narcoleptic syndrome is a life-long and sometimes familial disorder in which there is a disturbance of the rapid eye movement phase of sleep. Patients with periodic sleep in the daytime but no other symptoms seldom develop the narcoleptic syndrome and have a separate unrelated disorder. Twelve patients with the narcoleptic syndrome were treated separately with l(-) amphetamine and d(+) amph...
در مواردی سیستم ایمنی بدن باعث بروز بیماریهای ایمنی مانند آنمی همولتیک نوزادان hdn می شود. تنها راه پیشگیری ایزوایمونیزاسیون rh ، ،تجویز پارتابولین (anti-d) به مادران rh منفی بعد از تولد نوزاد rh مثبت می باشد. پیشگیری از آلوایمونیزاسیون ناشی از ترانسفوزیون و درمان itp از دیگر اندیکاسیونهای تجویز anti-d می باشد. روش acid elution برای شناسایی میزان fmh جهت تصحی...
BACKGROUND Solanum nigrum is claimed in traditional medical practice, to be useful in the treatment of epilepsy in some parts of Nigeria. OBJECTIVES To study the anti-convulsant property of the aqueous extract of the leaves of S. nigrum in chicks, mice and rats. METHOD Aqueous extracts were administered intraperitoneally, at a pre-treatment time of 30 minutes, at graded doses and animals we...
Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular monoamine transporter (VMAT) blocks amphetamine-induced locomotion and self-administration without impacting cocaine-induced behaviours. To study VMAT's role in mediating amphetamine action in dopamine neurons, we have used n...
Corticostriatal signaling participates in sensitized responses to drugs of abuse, where short-term increases in dopamine availability provoke persistent, yet reversible, changes in glutamate release. Prior studies in mice show that amphetamine withdrawal promotes a chronic presynaptic depression in glutamate release, whereas an amphetamine challenge reverses this depression by potentiating cort...
Stimulant sensitization is defined as an enhancement of the behavioral response to drug after repeated drug exposure. We have examined the relation between the expression of behavioral sensitization and the release of the striatal neurotransmitters acetylcholine (ACh) and dopamine (DA). Rats were treated with amphetamine (4 mg/kg i.p., b.i.d.) for 12 days. The behavioral response to amphetamine...
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