Background: Temporal lobe epilepsy (TLE) is the most common type of intractable and partial epilepsies. The only standard treatment for seizure-free status with manifest TLE surgical which includes amygdala-hippocampectomy. majority temporal seizures originate in mesial structures, primarily hippocampus, para hippocampal gyrus amygdala.

The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and warrant further examination. Hence, the present study investigated the function...

The etiopathogenesis of schizophrenia to date appears unclear. Multiple types research have focused attention on the possible etiological role amygdala. amygdala is involved in emotion processing, cognitive function, and social cognition; these aspects appear severely impaired schizophrenia. In this brief review, we will look at studies that correlated morpho-functional with psychopathological ...

Pavlovian fear conditioning is an experimental procedure in which a conditioned stimulus (CS) acquires an ability to elicit fear responses. This type of conditioning depends on the basolateral complex of the amygdala (BLA) and/or central amygdala (CeA). We previously found that rats showed reduced fear responses to an auditory CS when they were subjected to a pre-training chemical lesion of the...

BACKGROUND Central pain syndrome is characterized by a combination of abnormal pain sensations, and pain medications often provide little or no relief. Accumulating animal and clinical studies have shown that impairments of the spinothalamic tract (STT) and thalamocingulate pathway causes somatosensory dysfunction in central post-stroke pain (CPSP), but the involvement of other neuronal circuit...

Abstract The left dorsolateral prefrontal cortex (dlPFC) is a key region involved in emotion regulation and an effective target for repetitive transcranial magnetic stimulation (rTMS) treatment depression. Evidence shows that the dlPFC connects with amygdala, emotional responses processing, during regulation. Yet, our understanding of causal regulatory role on amygdala minimal. We performed 3 m...

low frequency stimulation (lfs) is a potential alternative therapy for epilepsy. however, it seems that the anticonvulsant effects of lfs depend on its target sites in the brain. thus, the present study was designed to compare the anticonvulsant effects of lfs administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. in control group, rats were kindled in ...

We examined the influence of extensive overtraining (75 trials) of auditory fear conditioning on the expression of conditional stimulus (CS)-elicited spike firing in lateral amygdala (LA) neurons. Single units were recorded from chronic multichannel electrodes implanted in the LA of conscious and freely moving rats. In sequential training sessions, the rats received either five or 70 fear condi...

The idea that the amygdala is crucially involved in automatically prioritising relevant events rests on evidence from a single lesion study where a patient with bilateral temporal lobe lesions, acquired in adulthood, was impaired in recall facilitation during the attentional blink. Here, in a comparable task, we show that two individuals with selective bilateral amygdala lesions retain facilita...