OBJECTIVE While much is known about the normal activation of platelets, there have been few observations demonstrating reversibility of the aggregation process. Inhibition of phosphoinositide 3-kinase (PI3-kinase) has been shown to cause platelet disaggregation. In addition, NO is a known potent inhibitor of platelet function. In this study, the role of PI3-kinase in the regulation of endogenou...

Proteins belonging to the B-subtype of the Hsp100/Clp chaperone family execute a crucial role in cellular thermotolerance. They cooperate with the Hsp70 chaperones in reactivation of thermally aggregated protein substrates. We investigated the initial events of the disaggregation reaction in real time using denatured, aggregated green fluorescent protein (GFP) as a substrate. Bacterial Hsp70 (D...

We consider the problem of overlap in the power draw between different appliances in nonintrusive load monitoring. We complement the power features by time-on and time-off statistics and use approximate semi-Markov models for robust computationally-efficient disaggregation. The superior disaggregation accuracy of our algorithm is demonstrated on actual household data.

The need for energy disaggregation increases with the need for a more detailed understanding and more accurate estimates about the energy usage. One of the main approaches for energy disaggregation is Non-Intrusive Load Monitoring (NILM). NILM refers to the analysis of the aggregate power consumption of electric loads in order to recognize the existence and the consumption profile of each indiv...

This study introduces a nonlinear deterministic approach for streamflow disaggregation. According to this approach, the streamflow transformation process from one scale to another is treated as a nonlinear deterministic process, rather than a stochastic process as generally assumed. The approach follows two important steps: (1) reconstruction of the scalar (streamflow) series in a multidimensio...

We analyze pricing strategies for digital information goods that are based on aggregation or disaggregation. Bundling, site licensing, and subscription pricing can be analyzed as strategies that aggregate consumer utility across different goods, different consumers, or different time periods, respectively. Using micropayments for rental of software “applets” or other discrete units of informati...

Originally, aggregation and disaggregation were considered as acceleration techniques similar to multigrid methods for the solution of linear systems of equations. Recently we have demonstrated that these methods can also be used for the numerical solution of the chemical master equation. Here three scenarios are discussed where aggregation and disaggregation accelerate convergence, reduce comp...

We examine twelve studies on the efficacy of disaggregated energy feedback. The average electricity reduction across these studies is 4%. However, 4% may be a positively-biased estimate of the savings achievable across the entire population because all twelve studies are likely to be prone to ‘opt-in’ bias hence none test the effect of disaggregated feedback on the general population. Disaggreg...

The Compute Express Link (CXL), a trademark of the CXL Consortium, protocol enables creating pools memory and accelerators, allowing disaggregation, composable virtual machines that make more efficient use memory. New software will even useful.