نتایج جستجو برای: angiotensin ii receptor

تعداد نتایج: 1146049  

Journal: :American journal of physiology. Heart and circulatory physiology 2001
M El Mabrouk R M Touyz E L Schiffrin

Angiotensin II-induced growth signaling mechanisms were investigated in vascular smooth muscle cells (VSMCs) from mesenteric arteries of spontaneously hypertensive (SHR) and Wistar-Kyoto rats (WKY). In WKY, angiotensin II significantly increased protein synthesis ([(3)H]leucine incorporation) but not DNA synthesis ([(3)H]thymidine incorporation). In SHR, angiotensin II increased protein and DNA...

Journal: :caspian journal of internal medicine 0
farshid oliaei shirin hushmand soraya khafri mahmoud baradaran

background: diabetic nephropathy is considered to be the most common cause of end stage renal disease (esrd). proteinuria is declared as the most marked risk factor in progression towards esrd. the aim of this study was to evaluate the efficacy of pentoxifylline for reduction of proteinuria in type ii diabetic patients. methods: from may 2007 to june 2008, this randomized clinical trial study w...

2013
Yu-Sheng Li Shu-Yuan Ni Ying Meng Xiao-Lan Shi Xu-Wen Zhao Hai-Hua Luo Xu Li

Angiotensin II has progressively been considered to play an important role in the development of liver fibrosis, although the mechanism isn't fully understood. The aim of this study was to investigate a possible pro-fibrotic mechanism, by which angiotensin II would enhance the pro-fibrotic effect of transforming growth factor beta 1 (TGF-β1) through up-regulation of toll-like receptor 4 (TLR4) ...

2014
Susanne Brand Kerstin Amann Philipp Mandel Anna Zimnol Nicole Schupp

INTRODUCTION Recently, we could show that angiotensin II, the reactive peptide of the blood pressure-regulating renin-angiotensin-aldosterone-system, causes the formation of reactive oxygen species and DNA damage in kidneys and hearts of hypertensive mice. To further investigate on the one hand the mechanism of DNA damage caused by angiotensin II, and on the other hand possible intervention str...

Journal: :Biomolecules 2021

Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates tyrosinate anion for receptor activation. Energy calculations were carried out to determine the preferred geometry CRS in presence and absence of Arg guanidino group occupying position 2 Ang II. These findings suggest that Tyr is over His bearing negative stabilized by group. Recent crys...

Journal: :Hypertension 1999
U Hilbers J Peters S R Bornstein F M Correa O Jöhren J M Saavedra M Ehrhart-Bornstein

NCI-H295, a human adrenocarcinoma cell line, has been proposed as a model system to define the role of the renin-angiotensin system in the regulation of aldosterone production in humans. Because the precise cellular localization of the components of the renin-angiotensin system in human adrenal cortical cells remains unclear, we investigated their localization in this defined cell system. NCI-H...

Journal: :Journal of the American College of Cardiology 1999
H P Brunner-La Rocca G Vaddadi M D Esler

One possible intervention to interrupt the deleterious effects of the renin-angiotensin system is suppression of angiotensin II (Ang II) formation by inhibition of angiotensin-converting enzyme (ACE). However, ACE inhibition incompletely suppresses Ang II formation and also leads to accumulation of bradykinin. Angiotensin II type 1 (AT1) receptors are believed to promote the known deleterious e...

Journal: :Hypertension 2002
Leszek Kalinowski Tomasz Matys Ewa Chabielska Włodzimierz Buczko Tadeusz Malinski

This study investigated the process of nitric oxide (NO) release from platelets after stimulation with different angiotensin II type 1 (AT1)-receptor antagonists and its effect on platelet adhesion and aggregation. Angiotensin II AT1-receptor antagonist-stimulated NO release in platelets was compared with that in human umbilical vein endothelial cells by using a highly sensitive porphyrinic mic...

Journal: :Endocrinologia japonica 1987
T Kono Y Kiso M C Khosla N Sakura

In order to detect the portion of the angiotensin II molecule binding to the human arteriolar receptor, angiotensin II-(1-5)-pentapeptide, angiotensin II-(1-4)-tetrapeptide and angiotensin II-(1-3)-tripeptide were infused intravenously as saline solutions into the same 5 normal men from 0900 h at a rate of 30 nmol (20 micrograms)/kg.min (1.2 ml/min) for 15 minutes, at a rate of 90 nmol (54.5 mi...

Journal: :iranian journal of basic medical sciences 0
farzin hadizadeh school of pharmacy, mashhad university of medical sciences, mashhad, iran biotechnology research center, mashhad university of medical sciences, mashhad, iran mohsen imenshahidi school of pharmacy, mashhad university of medical sciences, mashhad, iran payman esmaili biotechnology research center, mashhad university of medical sciences, mashhad, iran morteza taghiabadi school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. the effects of 5a and 5b on angiotensin receptors (at') and l-type calcium channels were investigated on isolated rat aorta. materials and methods aortic rings were pre-contracted with 1 pm angiotensin ii or 80 mm kcl and relaxant effects of losartan, nifedipine, 5a a...

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