The direct synthesis of N-arylated carbazoles through a palladium-catalyzed amination of cyclic iodonium salts with anilines is described. In particular, electron-poor aniline derivatives reacted smoothly with only 5 mol % of Pd(OAc)2 as catalyst to give the desired products in up to 71% yield. Furthermore, the reactivity of cyclic iodonium salts is compared with the reactivity of the correspon...

Chan-Lam cross coupling allowed efficient synthesis of N,N'-disubstituted ortho-phenylene diamines bearing strong electron donating or withdrawing groups, such as nitro or methoxy groups, with moderate to high yields. These diamines can then be turned into N-heterocyclic carbene precursors after condensation with trimethyl orthoformate. The same strategy can also be utilized for the synthesis o...

The amide containing structure is found chemistry and related science. As a consequence, methods for the N-acylation of amines occupies large place in organic chemistry. In this study, Zinc triflate acylation between aniline derivatives furan-2-carbonyl chloride was investigated under mild conditions. Also, different types amides obtained very good yields at room temperature purity after simple...

Under superacidic conditions, aniline and indole derivatives are sulfonylated at low temperature with easy-to-access arenesulfonic acids or arenesulfonyl hydrazides. By modification of the functional-group directing effect through protonation, this method allows nonclassical site functionalization by overcoming innate regioselectivity electrophilic aromatic substitution. This superacid-mediated...

A photocatalytic method for the α-selective hydroaminoalkylation of cinnamate esters has been developed. The reaction involves regioselective addition α-aminoalkyl radicals generated from aniline derivatives or aliphatic amines to α-position unsaturated esters. scope aromatic alkenes was extended styrenes undergoing with anti-Markovnikov selectivity, which confirms importance group at β-positio...