Neurotrophin-3 (NT-3), a member of the neurotrophin family, has been shown to be necessary for the development of muscle spindle and Merkel cell afferent nerve fibres in animal models. The presence of NT-3 in the suprabasal epidermis, where many unmyelinated sensory fibres terminate, has been shown for the first time. As these fibres are affected in early diabetic neuropathy and a clinical tria...

Sensory feedback from the moving limbs contributes to the regulation of animal and human locomotion. However, the question of the specific role of the various modalities is still open. Further, functional loss of leg afferent fibres due to peripheral neuropathy does not always lead to major alteration in the gait pattern. In order to gain further insight on proprioceptive control of human gait,...

Colorectal cancer is the third most prevalent cancer worldwide and the most common diet-related cancer, influenced by diets rich in red meat, low in plant foods and high in saturated fats. Observational studies have shown that fruit and vegetable intake may reduce colorectal cancer risks, although the precise bioactive components remain unclear. This review will outline the evidence for the rol...

Silicon carbide (SiC) dust and other dusts for comparison were injected intratracheally at a high dose (50 mg) into rats and the response of the lungs and the lymph nodes was studied after an appropriate experimental period. The indices studied were: histological changes in the lung and lymph nodes, organ weights, the formation of collagenous fibres, and the appearance of quartz typical areas. ...

Nociception is the detection of a noxious tissue-damaging stimulus and is sometimes accompanied by a reflex response such as withdrawal. Pain perception, as distinct from nociception, has been demonstrated in birds and mammals but has not been systematically studied in lower vertebrates. We assessed whether a fish possessed cutaneous nociceptors capable of detecting noxious stimuli and whether ...

Cotton fibres were subjected to cleaning process and then characterized for maturity. Decrystallisation and swelling processes with caustic soda, ethanol, propan-2-ol and Trichloroethene on the native fibres were carried out. The effects of these on the strength and moisture regain were investigated. The activation energies of the dyeings were also analysed with Durazol Scarlet Red 4 BAS. The r...

The association of cytochrome c oxidase negative fibres (COX-negative) and ragged-red fibres (RR-fibres) with work related trapezius myalgia has been proposed. Hitherto studies have been small or without control groups. The aim of the present study was to investigate the prevalences of RR-fibres and COX-negative fibres in female cleaners with (n=25) and without (n=23) trapezius myalgia and in c...

Our understanding of the ionic basis of axonal conduction has been largely derived from studies carried out on vertebrate and invertebrate animals which possess conventional body fluids containing relatively high concentrations of sodium and other inorganic ions. Apart from some recent studies on a phytophagous insect (Treherne, 1965 a, b; Treherne & Maddrell, 1967 a, b) we have very little kno...

In 1958 R. B. Clark and J. B. Cowey published a paper in which they presented a simple geometric model, based on the idea of a fibre-reinforced cylinder, to explain the mechanism underlying shape changes in ribbon worms and flatworms (Clark and Cowey, 1958). While their results may have been of interest to only a few biologists at that time, the essential idea of this paper, that a structure co...

OBJECTIVES Both sensory and sympathetic nerve fibres are depleted in the synovium in rheumatoid arthritis (RA). The hypothesis that the induction of an inflammatory response in the synovium is capable of causing depletion of nerve fibres was tested. METHODS To investigate this phenomenon experimental arthritis in the rat was induced by three different methods and the synovium was examined for...