The quotation above anticipates that loss of the proposed integrative functions of the claustrum might cause distinctive cognitive dysfunctions. Disconnection and degeneration of this structure might then contribute to cognitive and neuropsychiatric symptoms including those appearing in Alzheimer’s disease (AD). That the claustrum is important for at least some elements of the neuropsychologica...

Small electrolytic lesions were placed in the basal and lateral amygdaloid nuclei of the dog and the distribution of degenerating fibers was studied with Nauta and Fink-Heimer modifications of the impregnation methods. Degenerating axons were followed into the hippocampal region and entorhinal cortex as well as insular and temporal cortices. The present results suggest that: (i) The hippocampal...

The integration of neural signals from different sensory modalities is a prerequisite for many cognitive and behavioural functions. In this study, we have mapped the functional anatomy of the integration of sensory signals across the tactile and visual modalities. Using the PET radiotracer H2(15)O, regional cerebral blood flow (rCBF) changes were measured in eight normal volunteers performing c...

Recent studies of the Clare-Bishop (CB) area (the lateral suprasylvian area) have supported the role of this extrastriate, retinotopically-organized cortical region in visual and oculomotor functions. Anatomical studies were undertaken using retrograde horseradish peroxidase (HRP) techniques to define its afferent connections. Results indicate that CB receives substantial input from the ipsilat...