Introduction: Continued endemicity of intestinal nematodes infestation in children in our environment despite availability of potent and safe anthelmintic drugs is of public health interest. Objective: This study assessed the comparative efficacy of selected anthelmintic drugs namely Mebendazole, pyrantel pamoate and levamisole-against common intestinal nematodes namely Ascaris lumbricoides, Ho...

The attention is focused on the main classes of anthelmintics. Mode of action of the anthelmintics and the anthelmintic resistance, and alternative methods for dehelminthization are discussed. A targeted search for new anthelmintic substances in the series of speculative parental hydrocarbons (benzene, indene, naphthalene, 1 H1-cyclopenta [a]-naphthalene and phenanthrene) is suggested to be pro...

This study describes a biological investigations of methanolic extract of Jatropha gossypiifolia, a plant belonging to the family Euphorbiaceae. The aim of this investigation was to expose the viable phytochemical constituents properly as their contribution towards the antioxidant, anthelmintic and membrane stabilizing activities. The anthelmintic test was conducted on earthworm Pheritima phost...

Nerium olender popularly known as ’Indian olender’ in India belongs to family Apocyanaceae. The objective of the present work was to identify the phytochemical constituents and also to evaluate the in vitro anthelmintic potency of the aqueous extract of Nerium olender flower using Indian earthworms (Pheretima posthumad). The various concentrations (15, 25, 50 & 100 mg/ml) of the aqueous extract...

A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed goats in a semi-arid area in South Africa. In herds belonging to 10 small-holder goat farmers, the efficacies of fenbendazole, levamisole and rafoxanide were tested by faecal egg count reduction (FECR) tests. Efficacies of 80% were considered a threshold for anthelmintic resistance. The FECR te...

An ethanolic extract from the stem bark of Acacia oxyphylla, an indigenous anthelmintic plant among the Mizo tribes of north-east India, was tested in vitro to determine its anthelmintic activity on the fowl gastrointestinal cestode, Raillietina echinobothrida. The parasites were treated with varying concentrations, viz, 0.5, 1, 2, 5, 10, and 20 mg ml of the plant extract. On assessment of the ...

Malnutrition, anaemia, and gut parasites are commonly interrelated. Using the Nippostrongylus brasiliensis-rat model, the effect of iron and protein deficiency on the efficacy of benzimidazole anthelmintics was studied. It was demonstrated that the anthelmintics mebendazole and fenbendazole were significantly less effective in eradicating parasites when animals were deficient in iron and protei...

Sixty-five sheep farms in the northern provinces of Buenos Aires, Entre Rios, Corrientes, Cordoba and Sante Fe were used in this survey on anthelmintic resistance. Anthelmintic groups tested were the benzimidazoles, levamisole, the combination levamisole + benzimidazole product and the avermectins. The overall level of resistance was 46% of properties, with resistance to the individual drug gro...

matter is still one which has not been satisfactorily solved. The qualities to be sought in an anthelmintic are (1) safety for the patient; (2) effectiveness in expelling worms; (3) simplicity of administration on a large scale; (4) lack of unpleasantness in taking or in after effects; and (5) cheapness. No anthelmintic can be expected to reach perfection in any one of these attributes; the pro...

Malnutrition, anaemia, and gut parasites are commonly interrelated. Using the Nippostrongylus brasiliensis-rat model, the effect of iron and protein deficiency on the efficacy of benzimidazole anthelmintics was studied. It was demonstrated that the anthelmintics mebendazole and fenbendazole were significantly less effective in eradicating parasites when animals were deficient in iron and protei...