PURPOSE Anonymised, routinely-collected healthcare data is increasingly being used for epilepsy research. We validated algorithms using general practitioner (GP) primary healthcare records to identify people with epilepsy from anonymised healthcare data within the Secure Anonymised Information Linkage (SAIL) databank in Wales, UK. METHOD A reference population of 150 people with definite epil...

objectives juvenile myoclonic epilepsy(j.m.e.) needs life-long anti-epileptic drug (aed) treatment. of various drugs tried in this condition, valproate effectively treats all types of seizures seen in j.m.e. among valproate side effects, neural tube defects (ntd) in the offspring, is a deterring factor in its use in childbearing period. to avoid ntd, most authorities advise on switching to aed ...

Background: Epilepsy is a common chronic neurological disorder with more than half of cases beginning in childhood. Most patients require long-term, and sometimes life-long, therapy antiepileptic drugs (AEDs). AEDs are associated significant side effects including radiological evidence rickets, decreased bone mineral density (BMD), altered turnover, increased risk fracture.
 Aim the Study:...

BACKGROUND The presence of interictal epileptiform discharges (IEDs) in electroencephalogram (EEG) is diagnostic of epilepsy. Latent IEDs are activated during sleep. Anti-epileptic drugs (AEDs) improve sleep. AEDs, sleep, and IEDs may interact and affect epilepsy management. PURPOSE To explore the occurrence of IEDs and its association with sleep and AED status in suspected patients of epilep...

UNLABELLED The appearance of new anti-epileptic drugs (AED) during the last decade has provided neurologists and their patients with a greater choice, but the proof for their superiority over traditional AEDs is sparse, especially their use in adolescence and young adulthood. We studied a group of young adults (18-27 years) with epilepsy and compared their situation in 2004 with those 5 years e...

PURPOSE The choice of initial anti-epileptic drug (AED) for elderly and younger adult patients with newly diagnosed epilepsy was assessed. METHODS The pattern of initial prescription of AEDs between 2000 and 2013 was retrospectively studied in two community-dwelling cohorts, identified from the case records of Kuopio University Hospital (KUH): elderly subjects (aged 65 or above at the time of...

Background Epilepsy is a common complication in patients with severe motor and intellectual disabilities (SMID). There are no reports as yet of the effects of these medications in vivo other than their epileptic efficacy. The purpose of this study was to clarify the effects of the newer antiepileptic drugs (AEDs) on the blood biochemical parameters and oxidative stress in SMID with epilepsy by ...

UNLABELLED Antiepileptic drugs (AED) may cause body weight changes. OBJECTIVE To evaluate the dietary habits and body weight associated with AED in epileptic patients. METHOD Sixty-six patients were subjected to two interviews, and had their weight and body mass index calculated and compared at both times, interval between six to eight months. RESULTS It was observed that 59.1% showed wei...

Objectives and background: Juvenile myoclonic epilepsy (JME) has a similar clinical expression including excellent response to valproate (VPA) across different populations. We aimed to define the clinical and EEG features in patients and their relatives diagnosed to have JME whose seizures best responded to VPA alone versus those who required VPA and another anti-epileptic drugs (AED). Material...