Nifedipine is a dihydropyridine calcium-channel blocker (CCB) introduced approximately 30 years ago for the prophylaxis of angina symptoms, and then later utilized as an anti-hypertensive agent. In the 1990s, several meta-analyses and a case-control study were published which raised concern regarding increased mortality and increased risk for myocardial infarction with short-acting nifedipine. ...

PURPOSE Intravenous antihypertensive agents for the treatment of hypertensive emergencies are reviewed. SUMMARY An estimated 500,000 people in the United States experience a hypertensive crisis annually. Hypertensive emergency is associated with significant morbidity in the form of end-organ damage. Rapid controlled reduction of blood pressure (BP) may be necessary to prevent or minimize end-...

Bioactive peptides are generated during milk fermentation or enzymatic hydrolysis. Lactobacillus (L) helveticus is commonly used to produce some types of fermented products. Fermented derived bioactive known be beneficial in human health. Anti-hypertensive play a dual role the regulation hypertension through production vasoconstrictor angiotensin II and its inactivation vasodilator bradykinin. ...

Hypertension is condition medical moment pressure blood in arteries increase exceed normal limit. Various study has conducted for see effectiveness plant lower high, such as papaya mengkal and green grass jelly. In one said that there was a decrease hypertensive clients after giving juice. While jelly rich flavonoid alkaloid active substances. The content of substances can act anti-hepatotoxic,...

BACKGROUND Pro-arrhythmic concerns with most anti-arrhythmic agents in patients with significant left ventricular hypertrophy (LVH) limits options when anti-arrhythmic therapy is indicated. Ranolazine, an anti-anginal agent which inhibits late Na+ currents, indirectly causes a decrease in diastolic cardiomyocyte Ca++ levels producing an energy sparing effect. Ranolazine also inhibits triggered ...

BACKGROUND Epidemiologic studies have provided new insights into the association between psoriasis and cardiovascular diseases. Previous population studies have examined hypertension frequency in psoriasis patients. However, the relationship between severity of hypertension and psoriasis has not been characterized. OBJECTIVE We sought to investigate whether patients with psoriasis have more d...

curcumin is a natural polyphenolic compound with anti-cancer, anti-inflammatory, and anti-oxidation properties. low water solubility and rapid hydrolytic degradation are two challenges limiting use of curcumin as therapeutic agent. in the current study, the role of the bovine serum albumin (bsa), β-lactoglobulin and casein, as food-grade biopolymers and safe drug delivery systems, on the physic...