Pathological conditions that predispose to cardiovascular events, such as hypertension, hypercholesterolemia, and diabetes, are associated with oxidative stress. These observations and further data derived from a plethora of investigations provided accumulating evidence that oxidative stress is decisively involved in the pathogenesis of endothelial dysfunction and atherosclerosis. Several enzym...

Chronic inflammation increases lymphoma risk. Chronic inflammation exposes cells to increased reactive oxygen species (ROS). Constant exposure to ROS selects for oxidative stress-resistant cells with upregulated anti-oxidant defense enzymes. The impact of oxidative stress resistance on the redox biology and chemotherapy response in lymphoma has not been rigorously tested. To measure the effect ...

Although hyperhomocysteinemia (HHcy) elicits lower than normal body weights and skeletal muscle weakness, the mechanisms remain unclear. Despite the fact that HHcy-mediated enhancement in ROS and consequent damage to regulators of different cellular processes is relatively well established in other organs, the nature of such events is unknown in skeletal muscles. Previously, we reported that HH...

Dopamine, which is synthesized in the kidney, independent of renal nerves, plays an important role in the regulation of fluid and electrolyte balance and systemic blood pressure. Lack of any of the five dopamine receptor subtypes (D1R, D2R, D3R, D4R, and D5R) results in hypertension. D1R, D2R, and D5R have been reported to be important in the maintenance of a normal redox balance. In the kidney...

Nanomaterials are capable of generating reactive oxygen species (ROS) due to defect-induced electronic interactions with and water stimulated by environmental structural factors (e.g., photonic energy, band edge morphology) resulting in excellent pro-oxidant activity nanomaterials. The activities demonstrated the antibacterial nanomaterials under different conditions varying light levels). This...

The methanolic extracts were analyzed for anti-neoplastic enzymes screening, while antioxidant capabilities investigated fifteen isolates. also have enhanced radical scavenging ability against the stable ABTS (2,2’azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (86.34 ± 0.007 mM TE/g extract), nitric oxide (64.79 0.004 μg/ml), phosphomolybdenum (1.69 0.024 mg AAE/g FRAP (ferric reducing of pl...