development of antibiotic resistance in intensive care units (icus) is a worldwide problem. the purpose of this study was to evaluate the effect of an antibiotic stewardship program (asp) by carbapenems restriction on gram-negative antimicrobial resistance in icu. the study was designed in a 21 bedded general icu of a teaching hospital with two wings (one and two) in tehran, iran. carbapenem pr...

Antibiotic-resistant infections complicate treatment and increase morbidity and mortality. Mathematical modeling has played an integral role in improving our understanding of antibiotic resistance. In these models, parameter sensitivity is often assessed, while model structure sensitivity is not. To examine the implications of this, we first reviewed the literature on antibiotic-resistance mode...

sepsis is a significant cause of morbidity and mortality in neonates. the most common pathogens of bacterial sepsis and antibiotic sensitivity patterns vary in different parts of the world. the aim of this study was to determine the most common pathogens and outcome of neonatal sepsis and also antibiotic sensitivity patterns of klebsiella species. a retrospective descriptive study was carried o...

The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast, very little is known about the frequency and mechanisms underlying collateral sensitivity. In this case, genetic adaptation under antibiotic stress yields enhanced sensitivity to other antibiotics. Using large-scale laboratory evolutiona...

Abstract Background Based on the analysis of infections and antibiotic usage in years 2013 2014, an evidence-based protocol was developed implemented our cardiac surgical intensive care unit (CSICU). This study intends to impact this new sensitivity profiles common gram-negative bacteria CSICU. Methods The medical records patients who underwent surgery at center, between January 2017 December 2...

Meningitis is one of the most important causes of infant mortality and its early and proper diagnosis is of great importance, but there are currently no laboratory facilities optimized and fast in detection of meningitis pathogens. The current standard of bacterial meningitis diagnosis is microscopic examination and cerebrospinal fluid (CSF) culture. This research aimed at isolating the most co...

Development of antibiotic resistance in Intensive Care Units (ICUs) is a worldwide problem. The purpose of this study was to evaluate the effect of an antibiotic stewardship program (ASP) by carbapenems restriction on gram-negative antimicrobial resistance in ICU. The study was designed in a 21 bedded general ICU of a teaching hospital with two wings (one and two) in Tehran, Iran. Carbapenem pr...

Development of antibiotic resistance in Intensive Care Units (ICUs) is a worldwide problem. The purpose of this study was to evaluate the effect of an antibiotic stewardship program (ASP) by carbapenems restriction on gram-negative antimicrobial resistance in ICU. The study was designed in a 21 bedded general ICU of a teaching hospital with two wings (one and two) in Tehran, Iran. Carbapenem pr...

Changes over time in pathogens and their antibiotic sensitivity resulting from the recent overuse and misuse of antibiotics in otitis media (OM) have complicated treatment. This study evaluated changes over 5 years in principal pathogens and their antibiotic sensitivity in patients in Korea diagnosed with acute OM (AOM) and OM with effusion (OME). The study population consisted of 683 patients ...