Various bioactive compounds possessing the properties as antioxidant, antibacterial, antifungal, antimutagenic and anticancerous have been characterized and isolated from different parts of plants. Some studies in recent years have reported the occurrence of such bioactive compounds in pollen grains as well. Considering this, the present study was planned to examine antitumor activities of etha...

In recent years, the demands on drug discovery process have been increased dramatically, partly because of the necessity to recognize novel target that are both pertinent to disease and chemically tractable. The emergence of bioinformatics gives room to investigate diseases at the molecular level using computational techniques.The present work was to perform a molecular docking analysis of pote...

Rapidly developing field of nanobiotechnology dealing with metallic nanoparticle (MNP) synthesis is primarily lacking control over size, shape, dispersity, yield, and reaction time. Present work describes an ecofriendly method for the synthesis of silver nanoparticles (AgNPs) by cell free extract (CFE) of Saccharomyces boulardii. Parameters such as culture age (stationary phase growth), cell ma...

BACKGROUND Over 60% of currently used anti-cancer agents are derived in one-way or another from natural sources, including plants, marine organisms and microorganisms. Calotropis gigantea (Linn.) (Family: Asclepiadaceae) is a perennial shrub and it is used as a traditional folk medicine for the treatment of various health complications. But there is no report on isolation of anticancerous chemi...

Cancer is a life threatening disorder effecting 11 million people worldwide annually. Among various types of cancers, Hepatocellular carcinoma (HCC) has a higher rate of mortality and is the fifth leading cause of cancer related deaths around the world. Many chemotherapeutic drugs have been used for the treatment of HCC with many side effects. These drugs are inhibitors of different cell regula...

Objectives: Cetuximab is an anticancerous drug which causes oral mucositis as a major side effect. Oral mucositis can be reduced by the effect of grape seed extract which modulates the inflammatory pathways. Our aim is to evaluate the effect of Grape seed extract and Cetuximab drug on mucositis and bacterial infection in tongue mucosa of experimental rats. Design: 24 rats were housed in the ani...

Multidrug resistance (MDR) is a major cause of chemotherapy failure. It occurs when an organism is resistant to one type of drug, but also develops resistance to other drugs with different structures and targets. There is a high incidence of MDR in cancer chemotherapy, therefore, finding an effective and non-toxic MDR reversal agent is an important goal, particularly for P-glycoprotein-mediated...

Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery p...

Endophytic fungi live inside plants, apparently do not cause any harm to their hosts and may play important roles in defense and growth promotion. Endophytes are microorganism that lives between living plant cell. Their relationship may vary with plant from symbiotic to bordening on pathogenic. Endophytes may contribute to their host plant by producing a plethora of substances that provide prot...

The biblical balm of Gilead (Commiphora gileadensis) was investigated in this study for anticancerous activity against tumor cell lines. The results obtained from ethanol-based extracts and from essential oils indicated that β-caryophyllene (trans-(1R,9S)-8-methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene) is a key component in essential oils extracted from the balm of Gilead. β-Caryophylle...