abstract: in a wide search program towards new and efficient antimicrobial agents, a series of 4-substituted-1,2,4-triazolidine-3,5-dione derivatives namely urazoles holding an alkyl moiety at position 4 have been synthesized and tested for their in vitro antibacterial and antifungal activities. the structures of these compounds have been investigated by spectral data. the synthesized compounds...

Abstract Background Over the years, phytomedicines have been widely used as natural modalities for treatment and prevention of various diseases by different ethnic groups across globe. Although, 25% drugs in USA contain at least one plant-derived therapeutic compound, currently there is a paucity active medicinal ingredients pharmaceutical industry. Scientific evidence-based translation ethnome...

It is the purpose of thif; paper to review critically some of the methods and results of the past two decades in cancer research, a branch of pathology which has not failed to share in the general progress of medicine. During this period innumerable experiments have been performed, and the most diverse materials employed, in an endeavor to solve the problem of the cure of cancer. Thus Bra has e...

It was shown previously that the anticancerous cytotoxic oxygenated triterpenes, cucurbitacin E (Cuc E) and its deacetylated form, cucurbitacin I (Cuc I), interacted differently with human serum albumin. In this study, the biochemical stability of Cuc E was investigated in vitro by reverse-phase high performance liquid chromatography. The hydrolysis rate in acidic and alkaline solutions, and in...

Scarcity of protein rich food and food supplements are responsible for protein-energy malnutrition particularly among children and lactating women in the developing countries. Legumes and some dicotyledonous seeds constitute important sources of protein as well as energy. Bioprospecting of such unconventional sources is able to provide food security, agricultural development, self-dependence an...

Neutrophils represent the body's primary line of defense against invading pathogens. They most rapidly reach the site of injury or infection, liberate antimicrobial proteins, proteases and produce reactive oxygen species. Prolonged or excessive liberation of these very effective and toxic substances could intensify the inflammatory process and enhance tissue damage in many diseases, such as all...

Gemcitabine (2,2-difluorodeoxycytidine) is a deoxycytidine analog, currently being used as a first-choice drug in pancreatic metastatic cancer. Gemcitabine is administered weekly as 30-minute infusion with starting dose ranging from 800 to 1250 mg/m(2). The aim of the present work was to develop starch nanoparticles (NPs) for the delivery of gemcitabine hydrochloride that could reduce its dose ...

We have previously demonstrated that halofuginone, a widely used alkaloid coccidiostat, is a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 gene expression. Halofuginone also suppresses extracellular matrix deposition and cell proliferation. We investigated the effect of halofuginone on transplantable and chemically induced mouse bladder carcinoma. In both systems, oral a...

Triazole and itís derivatives are noteworthy for their physiological and biological importance. They paved the attention of medicinal chemist due to their wide range of biological activities like anti-inflammatory (1ñ5), antibacterial (6ñ8), anticonvulsant (9), antifungal (10ñ14) and anticancerous (15) etc. In view of above facts and inspired by the research going on triazole and its derivative...

UNLABELLED Plants continue to be a major source of medicines, as they have been throughout human history. In the present days, drug discovery from plants involves a multidisciplinary approach combining ethnobotanical, phytochemical and biological techniques to provide us new chemical compounds (lead molecules) for the development of drugs against various pharmacological targets, including cance...