In this study, the anti-cholinesterase activities of different extracts Achillea lycaonica, A. vermicularis and nobilis L. subsp. neilreichii (Kerner) Formanek species were examined then trace elements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Pb) plants analysed by ICP-MS. The pharmacokinetic properties phenolic compounds these previously analyzed us ADME-Tox (absorption, distribution, m...

Rutaecarpine is a pentacyclic indolopyridoquinazolinone alkaloid found in Evodia rutaecarpa and other related herbs. It has a variety of intriguing biological properties, which continue to attract the academic and industrial interest. Studies on rutaecarpine have included isolation from new natural sources, development of new synthetic methods for its total synthesis, the discovery of new biolo...

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. Cholinesterase inhibitors are widely used for the symptomatic treatment of Alzheimer's disease to enhance central cholinergic transmission. In this study, a bioactivity-oriented screening platform based on a modified Ellman's method and HPLC-QTOF MS technique was developed ...

This study is devoted to Musanga cecropioides (Urticaceae), a tropical plant whose leaves and root bark are used in traditional medicine the treatment of various pathologies. The objective this work was qualitative quantitative composition phenolic compounds extracts (McF) (McR) evaluate their antioxidant anticholinesterase properties. Phytochemical screening using TLC showed that contain, alon...

This paper is the first phytochemical and ABTS cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and DNA damage protection effect of endemic Verbascum pinetorum (Boiss.) O. Kuntze. Phenolic profile of V. pinetorum were qualified and quantified by UHPLC-ESI-MS/MS analysis. Malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were fo...

Background: Paper mulberry is one of the most common skin-lightening agents in beauty industry due to its strong anti-tyrosinase activity. This narrative review aims summarize chemical composition, biological activities, and applications paper cosmetics. Method: The literature for this article was acquired from PubMed, Web Science, Google Scholar databases before September 2022. keywords search...

Acetylcholinesterase (AChE) inhibitor is a basic drug design recently used in treating Alzheimer’s disease (AD). However, butyrylcholinesterase (BuChE) also suggested to be responsible for the hydrolysis of acetylcholine (ACh) and its inhibition may benefit in the latter stage of AD. Nonetheless, the search for potent AChE and BuChE inhibitor is still in need, in curing this neurodegenerative d...