Two young adults with lupus anticoagulant had multiple attacks of cerebrovascular ischemia in different arterial territories. Cerebral angiography was normal. One patient had a new episode during anticoagulant therapy, but has remained asymptomatic on antiplatelet treatment. In the other, further events occurred during treatment with platelet-inhibiting drugs, but there have been no recurrences...

A patient suffering from migraine, whose symptoms were abolished by warfarin therapy, is reported. Warfarin was prescribed for deep vein thrombosis and the frequency of the patient's headache improved remarkably during the anticoagulant therapy. Because of the unusual nature of the response to anticoagulant therapy, warfarin was reintroduced on a double blind (versus placebo) basis and once aga...

The effects of 3.2% and 3.8% sodium citrate concentration on the results of routine coagulation assays (prothrombin time [PT] and activated partial thromboplastin time [aPTT]) were evaluated by means of two sets of reagents, one responsive and the other nonresponsive. Five groups were entered in the study: healthy volunteers; outpatients receiving stable oral anticoagulant therapy; and hospital...

Purpose:AUA guidelines recommend ureteroscopy as first line therapy for patients on anticoagulant or antiplatelet and advocate using a ureteral access sheath. We examined practice patterns ...

IMPORTANCE Combined anticoagulant and aspirin therapy is associated with increased bleeding risk in patients with atrial fibrillation, but the bleeding risk of combined use of anticoagulant and nonsteroidal anti-inflammatory drugs (NSAIDs) is poorly documented. OBJECTIVE To estimate the bleeding risk of combined anticoagulant (rivaroxaban or enoxaparin-vitamin K antagonist [VKA]) and NSAID or...

BACKGROUND A high incidence of both arterial and venous thromboembolic events has been reported in patients with systemic lupus erythematosus (SLE), but the risks and benefits of primary prophylactic antithrombotic therapy have not been assessed. We measured the clinical benefit of 3 antithrombotic regimens in patients with SLE without antiphospholipid antibodies, with anticardiolipin antibodie...

Reassessment of Anticoagulant Therapy in Various Types of Occlusive Cerebrovascular Disease • Precise use of categorical terms and definitions is mandatory in discussing the use of anticoagulants in treating occlusive cerebrovascular disease. The components of the temporal profile of the disease are described. Six reports have appeared which describe the results of anticagulant therapy in trans...

Copyright: © 2017 Narayanan S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Sheshadri Narayanan, Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell Univ...

THE DISCOVERY of heparin by McClean in 1916' and the identification of bishydroxycoumerin (Dicumarol) by Link and his co-workers in 1934 as the agent responsible for sweet clover disease in cattle,2 stimulated studies of the clinical use of anticoagulant therapy. The excellent work of Jorpes,3 Zilliacus,4 Barker5" 6 of the Mayo Clinic, and Wright7'8 of New York, and others,9' 10, n has crystall...

T HE occurrence of inyocardial inifaretion and embolic incidents in patients with ischemic heart disease after cessation of anticoagulant therapy is well recognized.1-6 Likewise, the recurrence of intermittent ischemic attacks in the carotid and vertebro-basilar territory when anticoagulant treatment has been stopped has been described.7 These experiences have led to the suggestion that followi...