Objective: To investigate the antifungal activity of crude extract of leaves of Tamarix dioica tree. Material and Methods: Antifungal activity of crude extract of T. dioica leaves was studied. The extract was dissolved in Dimethyl Sulfoxide, then six strains of fungi were subjected to crude extract separately by agar tube dilution method. Inhibitory effect of extract in millimeters was determin...

Candida species have emerged as important and common opportunistic human pathogens, particularly in immunocompromised individuals. The current antifungal therapies either have toxic side effects or are insufficiently effect. The aim of this study is develop new small-molecule antifungal compounds by library screening methods using Candida albicans, and to evaluate their antifungal effects on Ca...

There has been a large increase in the incidence of invasive fungal infections (IFIs) over the past decades, largely because of the increasing size of the population at risk. One of the major risk groups for IFIs are patients with haematological malignancies treated with cytotoxic chemotherapy or undergoing haematopoietic stem cell transplantation. These IFIs are associated with high morbidity ...

Current antifungal therapies have limited effectiveness in treating invasive fungal infections. Furthermore, the development of new antifungal is currently unable to keep pace with the urgent demand for safe and effective new drugs. Auranofin, an FDA-approved drug for the treatment of rheumatoid arthritis, inhibits growth of a diverse array of clinical isolates of fungi and represents a new ant...

Currently, therapy of black-grain mycetoma caused by Madurella mycetomatis consists of extensive debridement of the infected tissue combined with prolonged antifungal therapy with ketoconazole or itraconazole. In the present study, the in vitro activity of the new triazole isavuconazole toward M. mycetomatis was evaluated. Isavuconazole appeared to have high activity against M. mycetomatis, wit...

The synthesis of novel mercury (II) complex with new ligands derived from Carbohydrazides has been reported. The complexes have general composition [ HgL2X2], Where L= Carbohydrazone and X = Cl-, NO3 . The ligand carbohydrazone behave as neutral bidentate Ligand through the carbonyl oxygen and azomethiene nitrogen. On the basis of elemental analysis, Electrochemical and spectroscopic studies, t...

The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited n...

Sea cucumber is presented as potential marine source of antimicrobial compounds. The purpose of this study is to evaluate antifungal effects of sea cucumber, Holothuria leucospilota, extracts on Aspergillus niger and Candida albicans. Methanol and chloroform extracts of the body wall, gonad and intestine of sea cucumber, H. leucospilota, collected from Persian Gulf, were evaluated for their ant...

Trials were conducted to compare a modification of a commercial medium with the 2 media currently used at the Veterinary Research Institute, Onderstepoort, for the isolation of Trichomonas foetus. An antifungal agent was also added to the medium. Results obtained proved the modified medium to be more reliable for the isolation of T. foetus than the other 2, and the addition of antifungal more e...

OBJECTIVES To assess the quality of antifungal use, to propose a point score for this evaluation and to estimate the potential economic savings of an antifungal stewardship programme. METHODS From December 2010 to January 2011, we identified 100 adult inpatients receiving systemic antifungals. Antifungal use was evaluated by means of a predefined score that considered indication, drug selecti...