New non aqueous based microemulsion allows the delivery of storage sensitive personal care actives in conventional cream, lotion and gel. Griseofulvin is an antifungal antibiotic drug micro emulsion system as the basic formulation for investigation. The quantity of griseofulvin and the accumulation of anhydrous micro emulsions at various temperatures were analyzed with poor aqueous solubility. ...

The aim of this study was to investigate antifungal activity of a range of different molecular weight (MW) chitosan against Penicillium italicum. Our results demonstrate that the antifungal activity was dependent both the MW and concentration of the chitosan. Among a series of chitosan derived from the hydrolysis of high MW chitosan, the fractions containing various sizes of chitosan ranging fr...

BACKGROUND In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely. METHODS Abafungin (chemical abstracts service registry No. 129639-79/8) is the first member of a novel class of synthetic antifungal compounds, the arylguanidines. It was first synthe...

Oral candidiasis is caused by Candida albicans. The symptoms including pain in the oral cavity affect our eating function. While some antifungal agents are commonly used for the treatment of candidiasis, occasional consumption of the effective dose cannot be tolerated due to side effects. There is also a possibility of induction of antifungal resistance, thus the development of replacement agen...

PURPOSE This in vitro study sought to compare the antifungal activity of melaleuca alternifolia oil and fluconazole mixed with a tissue conditioner. MATERIALS AND METHODS By testing several concentrations of fluconazole and melaleuca oil in Visco-gel, the minimum most effective concentration of each antifungal agent against Candida albicans was determined. Mean inhibition diameter (MID) was u...

This study was designed to evaluate the in vitro antifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oral Candida species, Candida albicans, Candida glabrata, Candida tropicalis, Candida kruse...

The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal and human cells. The most common antifungal targets include fungal RNA synthesis and cell wall and membrane component...

Background:Because of the increasing prevalence of fungal infections and antifungal resistance, researchers are seeking new antifungal medications and alternatives. This study aimed to assess the antifungal properties of Myrtus communis L. essential oil and hydroalcoholic extract on Candida species isolated from clinical specimens. Methods: A total of 65 Candida species isolated from clinical ...

BACKGROUND Given the high prevalence of oral candidiasis and the restricted number of antifungal agents available to control infection, this study investigated the in vitro antifungal activity of alcohol vinegar on Candida spp. and its effect on the physical properties of acrylic resins. METHODS Tests to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration...