background: iranian (lahijan) black tea caffeine has been previously shown to have antifungal activity against candida albicans. the aim of this study was to investigate whether the combination of caffeine and fluconazole (flu) has an effective antifungal activity on a flu-resistant (mic >64mgl-1) c. albicans ptcc5027. materials and methods: caffeine from lahijan black tea was extracted and its...

BACKGROUND Pityriasis versicolor (PV), also known as tinea versicolor, is caused by Malassezia species. This condition is one of the most common superficial fungal infections worldwide, particularly in tropical climates. PV is difficult to cure and the chances for relapse or recurrent infections are high due to the presence of Malassezia in the normal skin flora. This review focuses on the clin...

The central nervous system (CNS) distribution and antifungal efficacy of all 4 approved formulations of amphotericin B (AmB) were investigated in a rabbit model of hematogenous Candida albicans meningoencephalitis. Treatment with AmB deoxycholate (1 mg/kg/day) or liposomal AmB (5 mg/kg/day) yielded the highest peak plasma concentration (C(max)), area under concentration versus time curve from z...

BACKGROUND Neutropenic patients with persistent fever despite antibiotic therapy are managed with empirical or pre-emptive antifungal therapy. The aim of the present study was to evaluate the current clinical use and efficacy of these two approaches in patients with high risk hematologic conditions. DESIGN AND METHODS An electronic medical record system, the "Hema e-Chart", was designed and i...

PURPOSE OF REVIEW Lung transplantation remains the main therapy for patients with end-stage lung disease, yet survival remains limited by infection and chronic rejection. Invasive fungal infection, especially invasive aspergillosis, continues to cause a high rate of mortality after lung transplantation, and there is evidence that fungal colonization in itself may have a negative impact as well....

Caspofungin (MK-0991; L-743,872) belongs to the echinocandin family, a new class of antifungal agents that act on the fungal cell wall by inhibiting glucan synthesis. Data in vitro, and experimental studies, have demonstrated that caspofungin has antifungal activity against yeasts of the genus Candida (including isolates resistant to azoles and amphotericin B), several species of filamentous fu...

metallic silver nanoparticles have been reduced from silver nitrate by employing the extracellular enzymatic machinery of edible white button mushroom (agaricus bisporus). the physical properties of these particles, size and shapes have been determined using techniques like tem, ftir and xrd and were reported in our earlier report. but, what stands of paramount importance in the present context...

INTRODUCTION Invasive candidiasis is responsible for ∼ 10% of nosocomial sepsis in very-low-birth-weight infants and is associated with substantial morbidity and mortality. Over the last two decades, the antifungal armamentarium against Candida spp. has increased; however, efficacy and safety studies in this population are lacking. AREAS COVERED We reviewed the medical literature and extracte...

Butenafine (N-4-tert-butylbenzyl-N-methyl-1-naphtalenemethylamine hydrochloride) is an antifungal agent of the benzylamine class that has excellent therapeutic efficacy and a remarkably long duration of action when applied topically to treat various mycoses. Given the lipophilic nature of the molecule, efficacy may be related to an interaction with cell membrane phospholipids and permeabilizati...

background peganum harmala, glycyrrhiza glabra, mentha spicata and rosmarinus officinalis are often used in traditional medicine. objectives the current study aimed to screen the antifungal activity of ethanolic extracts of p. harmala, g. glabra, m. spicata and r. officinalis leaves collected from sistan region, iran against fusarium oxysporum. methods minimal inhibitory concentration (mic) and...