This research was conducted to formulate biodegradable itraconazole (ITZ)-loaded d-a-tocopheryl polyethylene glycol 1000 succinate-b-poly(e-caprolactone-ran-glycolide) (TPGS-b-(PCL-ran-PGA); TPP) nanoparticles (NPs) (designed as ITZ-loaded TPP NPs) to improve antifungal efficacy. ITZ-loaded TPP NPs were prepared by a modified double-emulsion method, and their size distribution, morphology, zeta...

The cysteine-rich, cationic, antifungal protein PAF is abundantly secreted into the culture supernatant of the filamentous Ascomycete Penicillium chrysogenum. The five β-strands of PAF form a compact β-barrel that is stabilized by three disulphide bonds. The folding of PAF allows the formation of four surface-exposed loops and distinct charged motifs on the protein surface that might regulate t...

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microspo...

BACKGROUND Chronic disseminated candidiasis (CDC) is typically observed during neutrophil recovery in patients with acute leukemia and requires protracted antifungal therapy. OBJECTIVE Our objective was to document the efficacy and tolerance of corticosteroid therapy (CST) in patients with symptomatic CDC, including those who experienced fever and abdominal pain despite ongoing antifungal the...

S100A8 and S100A9 and their heterocomplex calprotectin (S100A8/A9) are abundant cytosolic constituents in human neutrophils previously shown to possess antifungal activity. This study was designed to investigate mechanisms involved in the modulation of the antifungal properties of S100A8/A9. S100A8, S100A9 and site-directed mutants of both proteins were tested for their antifungal effect agains...

Andrographis macrobotrys Nees is an extensively utilized Indian traditional medicine to treat several human and livestock disorders. The present investigation was designed to evaluate the antibacterial, antifungal potentialities and phytochemical screening of the different leaves and stem extracts of Andrographis macrobotrys belongs to the family Acanthaceae. Methanol, ethanol, chloroform, acet...

Antifungal potential of aqueous extracts of forty plants of different families were tested against Fusarium oxysporum f.sp. ciceri causal agent of wilting of chick pea. Among forty plant species tested aqueous extract of Chenopodium ambrosioides has recorded significant antifungal activity against the test fungi. Solvent extracts viz. petroleum ether, benzene, chloroform, and methanol and ethan...

N -myristoyltransferase (NMT) has been an emerging target for the design of novel antifungal agents with new mode of action. A series of furan and imidazole containing heterocyclic derivatives have been designed using rational drug designing approach as NMT inhibitors. Newly Designed compounds were synthesized, characterized and evaluated for their antifungal activity against NMT. Synthesized c...