نتایج جستجو برای: antigen cd100
تعداد نتایج: 200259 فیلتر نتایج به سال:
OBJECTIVES Inappropriate activation of neutrophils plays a pathological role in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The aim of this study was to investigate the functions of semaphorin 4D (SEMA4D) in regulation of neutrophil activation, and its involvement in AAV pathogenesis. METHODS Serum levels of soluble SEMA4D were evaluated by ELISA. Blood cell-surfac...
Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases ErbB-2 and Met. In cells expressing the plexin-B1-ErbB-2 receptor complex, ligand stimulation results in the activation of small GTPase RhoA and stimulation of cellular migration. By contrast, in cells expressing plexin-B1 and Met, ligand stimulation results in an association wi...
OBJECTIVE In dyslipidemic states, platelets become hyperreactive, secreting molecules that promote atherosclerosis. We have shown that the semaphorin family member, sema4D (CD100), is expressed on the surface of platelets and proposed that its role includes promoting thrombus growth by binding to nearby platelets and endothelial cells, both of which express sema4D receptors. Here we tested the ...
Semaphorins, a large family of membrane-bound and secreted proteins, signal through their transmembrane receptors, the plexins. Semaphorins and plexins share structural homologies with scatter factor receptors, a family of tyrosine kinase receptors for which Met is the prototype. Semaphorins have been studied primarily in the developing nervous system, where they act as repelling cues in axon g...
Neovascularization occurring in atherosclerotic plaque leads to acceleration of plaque growth through increased leukocyte infiltration and reactive oxygen species (ROS) production. Sema4D (CD100), a class IV semaphorin, not only plays a crucial role in axon guidance but also functions in the neovascularization process of tumor growth. To clarify the roles of Sema4D in the progression of atheros...
background: anaphylactic reactions, such as urticaria, edema, respiratory symptoms, and anaphylactic shock often complicate the course of cystic echinococcosis (ce). methods: to investigate the role of the ige immunoreactive antigen 5 (ag 5) in the sero-positive patients with ce, we determined n-terminal of 57 kda subunit of ag5 responsible for ige and c-terminal of this active antigen related ...
تجزیه و تحلیل تراکنش بین سلول های ایمنی بدن و واکسیناسیون جهت درمان سرطان به وسیله یک مدل ریاضی تبیین شده توسط مشتقات مرتبه کسری در این تحقیق یک مدل ریاضی جهت تبیین تراکنش بین سلول های ایمنی و غده سرطانی، که به صورت یک دستگاه دینامیکی است، را مورد تجزیه و تحلیل قرار می دهیم. در این مدل تأثیر سلول های سیستم ایمنی بدن و برهم کنش بین آن ها بر روی دوره های نهفتگی و بازگشت بیماری سرطان مورد توج...
The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity to purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine, rat, cynomolgus macaque, and human sequences. The affinity for native SEMA4D expressed on macaque T lymphocytes was approximately 0.6 nmol/L. Tissues from rats and cynomolgus macaques demonstrated specific staining only with resident lym...
OBJECTIVE To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of VX15/2503 in a randomized, single-dose, dose-escalation, double-blind, placebo-controlled study enrolling adult patients with MS. METHODS Single IV doses of VX15/2503 or placebo were administered. Ten patients each were randomized (4:1 randomization ratio) into 5 ascending dose cohorts of 1, 3,...
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