نتایج جستجو برای: antigen presenting cells
تعداد نتایج: 1615635 فیلتر نتایج به سال:
Background: Falciparum malaria is a severe health burden worldwide. Antigen presenting cells are reported to be affected by erythrocytic stage of the parasite. Malarial hemozoin (HZ), a metabolite of malaria parasite, has adjuvant properties and may play a role in the induction of immune response against the parasite. Objective: To determine the immunological impact of hemozoin on the capacity ...
Abstract Atypical B cells are generated during a normal adaptive immune response, yet the role of these in protective immunity is still largely unknown. Here, we used chronic Plasmodium falciparum exposure as model to gain insight into function and potential heterogeneity atypical response infection. To this end, performed single-cell sequencing on circulating from malaria-experienced individua...
Dendritic cells (DCs) are the most important APC. It was recently reported that there is a dichotomy for Ag presentation by DC subsets; exogenous Ags reach the MHC class I pathway, but not the MHC class II pathway, in CD8(+) DCs, whereas CD8(-) DCs only process Ags for the MHC class II pathway. In this study, we used virus-like particles (VLPs) to show that CD8(+) and CD8(-) DCs efficiently cap...
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