This study investigated the in vivo genotoxicity of piquiá pulp (Caryocar villosum) and its potential antigenotoxicity on doxorubicin (DXR)-induced DNA damage by comet assay and micronucleus test. In addition, the phytochemicals present in piquiá pulp were determined. Piquiá fruit pulp (75, 150 or 300 mg/kg b.w.) was administered by gavage to Wistar rats for 14 days, and the animals received an...

Rhamnus alaternus L. is a Rhamnaceae shrub and popular traditional medicine in Algeria. The present research objective was to investigate the antioxidant, genotoxic, antigenotoxic properties of R. methanolic leaf extract. 
 Antiradical scavenging activity tested by α, α-diphenyl-β-picrylhydrazyl free radical β-carotene bleaching method. DNA damage repair were measured Allium cepa test with...

The development of various types of cancer results from the interaction among endogenous, environmental and hormonal factors, where the most notable of these factors is diet. The aim of the present study was to determine the antigenotoxic, anticarcinogenic, phagocytic and immunomodulatory activities of Agaricus blazei. The test antigenotoxicity (Comet Assay) and anticarcinogenic (Test of Aberra...

Hypothesis Anthocyanins possess well-known biological effects and suppress DNA damage induced by therapeutic topoisomerase poisons. Our study focusses on the modulatory effects of anthocyanidins-malvidin (MAL) and pelargonidin (PEL)-on topoisomerase II poison mitoxantrone (MXT)-induced cytotoxicity and genotoxicity in in vitro and in vivo conditions. Study design HepG2 cells were treated with M...

Egg yolk phosvitin is one of the most phosphorylated proteins in nature, and thus has a strong metal-binding ability. The objective of this study was to evaluate the cytotoxic and antigenotoxic activities of phosvitin in vitro. Using the 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, the cytotoxicity of phosvitin was evaluated in human cancer cell lines of various tiss...

Bitkiler tarafından ikincil metabolitler olarak sentezlenen doğal bileşiklerin, serbest radikallerin neden olduğu oksidatif strese ve bunların aracılık ettiği genetik hasara karşı koruyucu etkilerinin birçok araştırmada bildirilmiştir. Bu bileşikler arasında polifenollerin özellikle güçlü antioksidan aktiviteleri bilinmektedir. Euphorbiaceae, Geraniaceae Lythracea familyaları gibi bitki türünde...