A method for preparing uniformly dispersed cultures of Nocardia asteroides for use in tests for susceptibility to antimicrobial agents is described. The minimal inhibiting concentration (MIC) of 45 agents for cultures thus prepared was determined with the use of a replica-inoculating apparatus. Minocycline at a concentration of 3.1 ,ug or less/ml inhibited 90% of the strains tested, and all wer...

The main reason for the current unsatisfactory situation is that, worldwide, there is no effective regulation of the use of antibiotics. In many nations drugs are freely available "over the counterî and even in countries where most drugs are only available on prescription there may be little control. The practice in some societies of doctors prescribing the most potent drug available just in ca...

Despite its relatively good acid stability, ampicillin is absorbed rather poorly from the gastro-intestinal tract, varying from 30 to 50% (8, 10, 12). One of the attempts to achieve better absorption resulted in the development of pivampicillin, the pivaloyloxymethyl ester of ampicillin, which is rapidly hydrolyzed to ampicillin in the body; 15 min after administration, more than 99% of the dru...

the purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the ctpa on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, q...

The fungus is a eukaryotic organism which is classified as a separate kingdom from plants, animals and bacteria. The fungus kingdom is divided into one subkingdom, seven phyla, and ten subphyla having a vast diversity of taxa with varied ecologies, life cycle strategies, and morphologies ranging from single-celled aquatic hybrids to large mushrooms. They are omnipresent, comprising an estimated...

Antimicrobial host defense peptides are produced by all complex organisms as well as some microbes and have diverse and complex antimicrobial activities. Collectively these peptides demonstrate a broad range of antiviral and antibacterial activities and modes of action, and it is important to distinguish between direct microbicidal and indirect activities against such pathogens. The structural ...

Limit the abstract to 250 words or fewer and concisely summarize the basic content of the paper without presenting extensive experimental details. Avoid abbreviations and references, and do not include diagrams. When it is essential to include a reference, use the same format as shown for the References section but omit the article title. Conclude the abstract with a summary statement. Because ...

Three cephalosporin-related antibiotics and nine other antimicrobial agents were studied for in vitro effectiveness against 54 recently isolated strains of Salmonella. Minimal inhibitory concentrations determined by the plate dilution method demonstrated the following percentages of resistance: ampicillin, 6%; tetracycline, 13%; streptomycin, 52%; sulfadiazine, 94%; cephaloglycin, 96%; and linc...

Emergence of resistance by bacterial and fungal stains towards existing antimicrobial agents is one of the major problem as well as motivation to synthesize a new class of antimicrobial agents possessing potent activity compared to commonly used therapy. Coumarin is the heterocyclic compound formed from benzene and pyrone ring containing oxygen and its derivatives are of wide awareness because ...

The purpose of this research was to study the neutralization efficacy of a universal neutralizer proposed by the CTPA on a range of antimicrobial agents and its potential toxicity for microorganisms that are used for antimicrobial preservation testing. Several types of antimicrobial agents including a mixture of methylisothiazolinone and its 5-chloro derivative, dimethylol dimethyl hydantoin, Q...