The characterization of ABCI4, a new intracellular ATP-binding cassette (ABC) half-transporter in Leishmania major, is described. We show that ABCI4 is involved in heavy metal export, thereby conferring resistance to Pentostam, to Sb(III), and to As(III) and Cd(II). Parasites overexpressing ABCI4 showed a lower mitochondrial toxic effect of antimony by decreasing reactive oxygen species product...

Antimony compounds are the cornerstone treatments for tegumentary leishmaniasis. The reactivation of herpes virus is a side effect described in few reports. We conducted an observational study to describe the incidence of herpes zoster reactivation during treatment with antimony compounds. The global incidence of herpes zoster is approximately 2.5 cases per 1,000 persons per month (or 30 cases ...

The participation of trypanothione in clinical and experimental antimony (Sb) resistance in Leishmania panamensis was examined by using specific inhibitors. Buthionine sulfoximine (BSO) significantly reversed the resistance to trivalent Sb (Sb(III)) of promastigotes of experimentally derived Sb-resistant lines, supporting the participation of a trypanothione-mediated mechanism of resistance. In...

A novel fluorescent nanosensor for Sb(3+) determination was reported based on thioglycolic acid (TGA)-capped CdTe quantum dot (QD) nanoparticles. It was the first antimony ion sensor using QD nanoparticles in a receptor-fluorophore system. The water-soluable TGA-capped CdTe QDs were prepared through a hydrothermal route, NaHTe was used as the Te precursor for CdTe QDs synthesis. Bovine serum al...

Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly of displaying anti-cancer and oncogenic properties simultaneously. Some antim...

This work reports the use of non-traditional fillers as flame retardants in polyester resin composites. Studies have been carried out to evaluate the fire-retardant properties of non-traditional fillers viz. hydroxyapatite, zinc borate and fly ash in combination with traditional fire retardant filler antimony trioxide, in prepolymer polyester resin composite system. Polyester resin was synthesi...

N. Eddaikra, K. Aït-Oudhia, B. Oury, Z. Harrat and D. Sereno Service d’eco-épidémiologie Parasitaire et Génétique des Populations Parasitologie, Institut Pasteur d'Algérie, Dely Ibrahim, Alger, Algeria. Ecole Nationale Supérieure Vétérinaire d’Alger, BP 161. Hassan Badi El-Harrach. Alger. Algeria. MIVEGEC (UM1-CNRS 5290-IRD 224) Institut de Recherche pour le Développement (IRD), BP 64501, 34394...