Epilepsy and neurocysticercosis are common neurological disorders major public health issues that contribute to the world’s burden of disease. Acute symptomatic seizures, main clinical manifestation parenchymal neurocysticercosis, caused by host brain immune-inflammatory process in response death or degenerative phase parasite. Seizures may recur over course several months while local inflammat...

Throughout the tropical and subtropical climates, genus Citrus can be found. The current study was conducted to extract sinensis peel oil evaluate its antibacterial, antifungal antiparasitic potential. Petroleum ether used C. through a Soxhlet apparatus. antimicrobial potential determined via agar well diffusion method minimum inhibitory concentrations (MIC) were calculated (test bacterial stra...

The leishmaniasis and Chagas diseases constitute a serious public health problem worldwide with few and ineffective treatment options. The search for new antiparasitic candidates at the initial steps of drug discovery and development is still necessary. The synthesis of 22 de novo synthetized N,N'-dihetaryl-alkyldiamine derivatives and in vitro antiparasitic activity were evaluated for the firs...

This paper reports the in vitro trypanocidal activity evaluation of new carbohydrazide derivatives from 3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine, substituted at C-6 position by phenyl, methyl or trifluoromethyl group. These compounds were evaluated in order to identify the antiparasitic profile against trypomastigote and amastigote forms of Trypanosoma cruzi. The 4-carbohydrazide derivative...

BACKGROUND Malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations. Ketolides antibiotics are used for treatment of various ailments and are relevant candidates to establish antiparasitic activity. OBJECTIVES The present study investigates the activity of ketolide co...