نتایج جستجو برای: antiproliferative protein
تعداد نتایج: 1241720 فیلتر نتایج به سال:
The molecular mechanism responsible for cell fate after mitotic slippage remains unclear. We investigated the different postmitotic effects of aneuploidy versus polyploidy using chemical inhibitors of centromere-associated protein-E (CENP-E) and kinesin family member 11 (KIF11, also known as Eg5). Aneuploidy caused substantial proteotoxic stress and DNA damage accompanied by p53-mediated postmi...
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling. The mainstay of chemotherapy treatment of CRC is 5-fluorouracil (5FU) and oxaliplatin. The two anticancer drugs mediate their therapeutic effect via DNA damage-triggered signaling. The small molecule reactivating p53 and induc...
Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides.
The discovery of G-rich oligonucleotides (GROs) that have non-antisense antiproliferative activity against a number of cancer cell lines has been recently described. This biological activity of GROs was found to be associated with their ability to form stable G-quartet-containing structures and their binding to a specific cellular protein, most likely nucleolin (Bates, P. J., Kahlon, J. B., Tho...
Retinoid-related molecules (RRM) are novel agents with tumor-selective cytotoxic/antiproliferative activity, a different mechanism of action from classic retinoids and no cross-resistance with other chemotherapeutics. ST1926 and CD437 are prototypic RRMs, with the former currently undergoing phase I clinical trials. We show here that ST1926, CD437, and active congeners cause DNA damage. Cellula...
OBJECTIVE Synthesis and maturation of G protein-coupled receptors are complex events that require an intricate combination of processes including protein folding, posttranslational modifications, and transport through distinct cellular compartments. Little is known concerning the regulation of G protein-coupled receptor transport from the endoplasmic reticulum to the cell surface. METHODS AND...
Medicinal plants contain numerous bioactive molecules that synergistically provide therapeutic benefits. We have devoted our attention to various EOs without toxicity normal cells, studying their activities against human cancer cells. In particular, we studied the cytotoxicity of Vepris macrophylla (Baker) I. Verd. EO. V. is an evergreen tree Madagascar where much appreciated as a source tradit...
Published Ahead of Print 26 November 2007. 10.1128/MCB.01136-07. 2008, 28(3):1018. DOI: Mol. Cell. Biol. Haruhiko Koseki and Miguel Vidal Serrano, Teresa Melgar, Mitsuhiro Endoh, Claudia Pérez, Carmela Calés, Mónica Román-Trufero, Leticia Pavón, Iván Deletion Ink4a Associated with Cooperation with Tumorigenesis Hematopoietic Cell Expansion and Ring1B Unveils an Antiproliferative Role in Inactiv...
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