Considering the therapeutic aspects of thyrotoxicosis, 980 cases were studied, where probable role of stress in the etiopathogenesis has been explored. These cases were then treated with standard modern therapy containing antithyroid drug with a tranquilizer and some of the patients were treated only by an Ayurvedic drug. i. e. Sankhapuspi. In early cases Sankhapuspi was found more effective th...

Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presents with focal or diffuse nonenhancing MR imaging abnormalities in 50% of patients with SREAT during subacute exacerbation. Vasculitic changes in biopsy studies as well as the elevation of antithyroid antibodies and CSF protein suggests an inflammatory cause. We report the case of a patient with SREAT with cha...

OBJECTIVE To determine the effect of adjunctive antithyroid drugs on the risk of treatment failure, hypothyroidism, and adverse events after radioiodine treatment. DESIGN Meta-analysis. DATA SOURCES Electronic databases (Cochrane central register of controlled trials, Medline, Embase) searched to August 2006 and contact with experts. Review methods Three reviewers independently assessed tri...

BACKGROUND Optimal treatment of Graves' disease in paediatric patients is still a matter of controversy. Antithyroid drugs, radioiodine and thyroidectomy are the three therapeutic options available. AIM To report our experience of long-term medical treatment and outcome of paediatric Graves' disease. METHODS A 5-y-long medical protocol was implemented in 20 children and adolescents with Gra...

Methimazole (MMI) and propylthiouracil (PTU) are the main antithyroid drugs used for hyperthyroidism. They inhibit the synthesis of thyroid hormone at various levels and are used as the primary treatment for hyperthyroidism or as a preparation before radioiodine therapy or thyroidectomy. MMI is the drug of choice because of its widespread availability, longer half-life and small number of sever...

A 3 year old child with Graves' disease and mitral valve prolapse became neutropenic on carbimazole therapy. She was switched to propylthiouracil but the neutropenia recurred. She was treated with radioiodine but required two doses of 113 MBq and then 198 MBq five months later before becoming hypothyroid. The mitral valve prolapse resolved when she was euthyroid on thyroxine replacement. Antith...

We describe a case of severe congestive heart failure and right ventricular overload associated with overt hyperthyroidism, completely reversed with antithyroid therapy in a few week. It represents a very unusual presentation of overt hyperthyroidism because of the severity of right heart failure. The impressive right ventricular volume overload made mandatory to perform transesophageal echo an...

Thyrotoxicosis due to Graves disease is a relatively common endocrine disorder. The occurrence of a prolactinoma with co-secretion of growth hormone (GH) is on the other hand, rare. We report the rare co-existence of Graves' disease in a patient with macroprolactinoma and GH hypersecretion and describe the successful response to medical therapy with dopamine agonist and antithyroid therapy. We ...

This is a retrospective study on clinical course and treatment response of patients with thyroid hot nodule, referred to nuclear medicine department of Shariati Hospital from 1360 to 1377. From the total 58 patients with average age of 43 yr and incidence peak of 40 yr, 81% were female and 19% were male. 64% of the patients were thyrotoxic and 36% were euthyroid at presentation. Thyrotoxi...