Keeping in view the drawbacks associated with research on anti-TB drugs based on plant extracts and the non-availability of fluorinated natural products with antitubercular activity has prompted us to make an effort towards the synthesis and characterization of a novel series of fifteen substituted fluorobenzimidazoles. The newly synthesized compounds were characterized by I.R, 1H-NMR, 13C-NMR,...

A series of 2-amino-4H-pyran-3-carbonitrile derivatives were designed and synthesized. Their antitubercular activities were evaluated against autoluminescent M. tuberculosis H37Ra and standard strain M. tuberculosis H37Rv. No obvious antitubercular activities could be observed (MIC > 10 g/mL). The results are in sharp contrast with the previously reported data.

Introduction: Tuberculosis is one of the most common diseases in developing countries, resulting in significant morbidity and mortality. Tuberculosis has varied clinical presentations, varying from common primary pulmonary tuberculosis to the extremely rare tubercular otitis externa, as in this case. Tubercular otitis externa has an extremely low clinical incidence.   Case Report: We report the...

introduction: tuberculous otitis media (tom) is an uncommon, insidious, and frequently misdiagnosed form of tuberculosis (tb). in particular, tom is usually secondary to direct transmission from adjacent organs, while the primary form has been rarely reported. the main aim of treatment is to start the patient on an antitubercular regime and early surgical intervention to decompress the facial n...

Erythema induratum of Bazin (EIB) is a chronic nodular eruption that frequently occurs on lower legs young or middle-aged women. The clinical manifestations EIB revealed various dermatological disorders can be easily leads to misdiagnosis. We report case 50-year-old woman who initially presented with EIB. histopathological specimen was collected from her medial aspect let leg. epidermis unremar...

Owing to the persistence of tuberculosis (TB) as well as the emergence of multidrug-resistant and extensively drug-resistant (XDR) forms of the disease, the development of new antitubercular drugs is crucial. Developing inhibitors of shikimate kinase (SK) in the shikimate pathway will provide a selective target for antitubercular agents. Many studies have used in silico technology to identify c...

Thirty five patients of either sex suffering from tuberculosis were administered streptomycin 0.75 g (im daily, upto 14 yr and above 45 yr of age) and 1 g (im daily for age 15-45 yr) with other antitubercular drugs and followed for audiological status. Five patients were dropped as they developed vestibular dysfunction. Varying degree of hearing loss was detected in 4 of 10 patients in group I ...