Apelin and its receptor APJ have pleiotropic effects in mice and humans and play a protective role in cardiovascular diseases at least partially by inhibiting oxidative stress. Our objective was to study the effect of apelin on the progression of kidney disease in mice with established type 1 diabetes. Ove26 mice with type 1 diabetes received daily subcutaneous injections of apelin for 2 or 14 ...

Apelin is the peptidic ligand for the G-protein-coupled receptor APJ. The apelin-APJ system is important in cardiovascular regulation, fluid homeostasis, and angiogenesis, among other roles. In this study, we investigate interactions between apelin and membrane-mimetic micelles of the detergents sodium dodecyl sulfate (SDS), dodecylphosphocholine (DPC), and 1-palmitoyl-2-hydroxy-sn-glycero-3-[p...

Apelin is a recently discovered peptide, identified as an endogenous ligand of receptor APJ. Apelin and receptor APJ are expressed in a wide variety of tissues including heart, brain, kidneys and lungs. Their interaction may have relevant pathophysiologic effects in those tissues. In fact, the last decade has been rich in illustrating the possible roles played by apelin in human physiology, nam...

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Aim: A testicular germ cell tumour is not observed widely, but its incidence and mortality rates have increased in recent years. One of the most common forms this seminoma. Germ neoplasia situ (GCNIS) precursor The apelin/APJ axis many cancers a pathway that plays an active role angiogenesis, lymphangiogenesis, growth, migration. This study investigated cellular distributions apelin APJ protein...

We describe Hubble Space Telescope (HST) imaging of 10 of the 20 ESO Distant Cluster Survey (EDisCS) fields. Each ∼40 square arcminute field was imaged in the F814W filter with the Advanced Camera for Surveys Wide Field Camera. Based on these data, we present visual morphological classifications for the ∼920 sources per field that are brighter than I auto = 23 mag. We use these classifications ...

The G protein–coupled receptor (GPCR) APJ (X-msr, angiotensin receptor like 1b) was cloned in several laboratories by homology screening, with the goal of identifying new members of this class of cell surface receptor.1 This gene attracted attention because of its sequence similarity to the important angiotensin II type 1 receptor and its highly restricted pattern of expression in endothelial c...

The flux upper limits of the diffuse gamma rays, from the inner and outer Galactic planes, are revised by factors of 4.0∼3.7 for mode energies 3∼10 TeV, respectively, by using the simulation results of the effective area ratios for gamma-ray induced showers and cosmic-ray induced ones in the Tibet air shower array. In our previous work, (Amenomori et al., ApJ, 580, 887, 2002) the flux upper lim...

Background/Aim: Colon cancer is the second deadliest malignancy for human. Its correlation with obesity has led to an increasing number of studies focusing on role adipokines in colon development. Apelin, which belongs family adipokines, affects several pathological processes, including heart diseases, and carcinogenesis. In this study, we examined importance apelin receptor (APJ) during motili...