background and objective: the main causes of nocturnal hypoxemia are pulmonary diseases or sleep related breathing disorders. in overlap syndrome, the co-existence of chronic obstructive pulmonary disease (copd) and ob-structive sleep apnea (osa), blood oxygen alteration, and hypercapnia may be more severe. we aimed to study hypox-emia markers in osa patients with or without copd. materials and...

1515 OBSTRUCTIVE SLEEP APNEA-HYPOPNEA SYNDROME (OSAHS) IS CHARACTERIZED BY REPEATED EPISODES OF UPPER AIRWAY OBSTRUCTION DURING SLEEP, with disturbances in arterial blood gases and increasing inspiratory effort until the upper airway obstruction discontinues due to arousal. OSAHS has a relatively high prevalence and occurs in 5% of the adult population.1 OSAHS may cause daytime sleepiness, redu...

BACKGROUND AND PURPOSE Sleep-disordered breathing (SDB) negatively impacts stroke outcome. Near-infrared spectroscopy showed the acute cerebral hemodynamic effects of SDB. METHODS Eleven patients (7 men, age 61±13 years) with acute/subacute middle cerebral artery stroke (National Institutes of Health Stroke Scale score 10±7) and SDB (apnea-hypopnea index 32±28/hour) were assessed with nocturn...

We have shown previously that the inactivation of the zinc finger gene Krox-20 affects hindbrain segmentation, resulting in the elimination of rhombomeres 3 and 5. We demonstrate here that Krox-20 homozygous mutant mice exhibit abnormally slow respiratory and jaw opening rhythms, indicating that a modification of hindbrain segmentation influences the function of neuronal networks after birth. C...

Twelve subjects with Down syndrome underwent polysomnographic studies during night sleep and performed the Mini-Mental state test and the Raven Progressive Matrices (RPM), sets A, B, and B(1). Sleep-disordered breathing (SDB) deficits were observed in Down syndrome individuals and their Mini-Mental and RPM scores were extremely low. Regression analysis of the results revealed that the number of...