Uremic dyslipidemia is an important risk factor for accelerated atherosclerosis, contributing to the many times higher cardiovascular mortality of hemodialysis (HD) patients (pts) in comparison to nonuremic population1. The influence of genetic determinants in this disorder has been widely studied, including apo E genetic variation and its relationship to cardiac and cerebrovascular disease. Ow...

We investigated the role of the apolipoprotein (Apo) E polymorphism in the prediction of CAD age of onset in a sample of unrelated living male (n = 65) and female (n = 54) Caucasian subjects diagnosed with CAD. Cumulative distributions of age at the first diagnosis of CAD were estimated for each Apo E genotype and tested for homogeneity using the log-rank test. The Apo epsilon 33 genotype was u...

In human populations, there is an association between coronary artery disease and a polymorphism in the apolipoprotein B (apo B) gene detected with the enzyme EcoRI. This polymorphism gives rise to two apo B alleles, one (E+) encoding glutamic acid and the other (E-) encoding lysine at position 4,154 in apo B-100, the protein of low density lipoprotein (LDL). We have tested the hypothesis that ...

In human populations, there is an association between coronary artery disease and a polymorphism in the apolipoprotein B (apo B) gene detected with the enzyme EcoKl. This polymorphism gives rise to two apo B alleles, one (E) encoding glutamic acid and the other (E~) encoding lysine at position 4,154 in apo B-100, the protein of low density lipoprotein (LDL). We have tested the hypothesis that t...

Serum apolipoprotein (apo) E concentrations were determined by immunoturbidimetry in 4284 subjects from 4 to 71 years of age and belonging to 1003 nuclear families recruited for the STANISLAS cohort study between January 1994 and August 1995. Values for apo E ranged from 16 to 169 mg/L, with a geometric mean +/- SD values of 46.6 +/- 13.8 mg/L in the overall sample. The interindividual variabil...

BACKGROUND Apolipoprotein (apo) E is a component of two major classes of plasma lipoproteins, apo B- (apo E-LpB) and non-apo B-containing (apo E-Lp-non-B) lipoproteins. The factors that affect total apo E in particles [lipoprotein E (LpE), apo E-Lp-non-B, and apo E-LpB], are incompletely characterized. METHODS We studied the determinants of these lipoparticles in a sample population of presum...

To examine the concentration of serum lipoproteins and the association of their genetic variation with the occurrence of coronary artery disease (CAD), composite serum lipoprotein profiles including lipoprotein(a) (Lp[a]), apolipoprotein (apo) E phenotypes, and apo BXba I genotypes were determined in patients with angiographically verified CAD (CAD+ group, n = l l l ) and in subjects with no an...

BACKGROUND The most common apolipoprotein E (apoE) gene polymorphism has been found to influence plasma lipid concentration and its correlation with coronary artery disease (CAD) has been extensively investigated in the last decade. It is, however, unclear whether apoE gene polymorphism is also associated with increased risk of type 2 diabetes mellitus (T2DM). The knowledge of this study may pr...

A functional polymorphism of the brain-derivedneurotrophic factor (BDNF Val66Met) has been reported to affectmemory-related hippocampal activity. Apolipoprotein E (ApoE)gene polymorphism is known to be associated with Alzheimerdisease (AD), dementia with Lewy bodies (DLB), and Pick disease(PiD). We tested the hypothesis that BDNF Val and ApoE e4alleles confer susceptibil...