Background: Dexmedetomidine has been reported to induce anti-apoptotic effects and metastatic progression in lung cancer. In the current investigation, effect of β-Caryophyllene on dexmedetomidine induced cell proliferation apoptosis cancer cells tumor growth mice was studied. Methods: A549 line cultured with either alone or together for 24 h analysed MTT assay. ELISA based kit used determine a...

Gamithromycin and tulathromycin are commonly used in the treatment of bovine respiratory bacterial diseases. The current work was undertaken to establish apoptotic, necrotic, cytotoxic effects these antibiotics target animal. Cells with apoptosis necrosis were determined by dual staining method, MTT assay, cell proliferative examined XCelligence real-time analysis system (RTCA-SP). comparison b...

BACKGROUND Celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, has a pro-apoptotic effect on colon adenocarcinoma cells via COX-independent mechanisms. MATERIALS AND METHODS The pro-apoptotic effect of N-(2-Aminoethyl)-4-[5- (4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (TT101), a new derivative of celecoxib, was investigated on the HT-29 and SW480 colon adenocarcinom...

objective: this study is an attempt to examine the anti apoptotic effects of bio on rat msc culture. materials and methods: rat marrow primary cell culture was established and exposure groups were defined; cultures with 0.01, 0.1, 1 μm bio. cells cultured without bio treatment were used as controls. during culture expantion, the average doubling time, as an index of the rate of cell growth, wer...

objective: extracellular deposition of the beta-amyloid (aβ) peptide, which is the main finding in the pathophysiology of alzheimer’s disease (ad), leads to oxidative damage and apoptosis in neurons. melissa officinalis (m. officinalis) is a medicinal plant from the lamiaceae family that has neuroprotective activity. in the present study we have investigated the protective effect of the acidic ...

Abstract This study was to investigate whether high-intensity interval training (HIIT) and saffron aqueous extract (SAE) would provide a synergistic effect improve tumor volume reduction also modulate pro- anti-apoptotic protein expression in tissue of 4T1 breast cancer-bearing mice. Female mice following induction cancer through injection cell lines were randomly divided into four groups: (1) ...

Fractalkine (FKN) is a chemokine with several roles, including chemotaxis; adhesion; and immune damage, which also participates in cell inflammation apoptosis responds to the pathogenesis of autoimmune diseases. Given involvement regulatory T cells (Treg) diseases, this study investigated mechanism FKN renal injury Treg via p38 mitogen-activated protein kinase (p38MAPK) signaling pathway lupus-...

BACKGROUND Osteopontin (OPN) is a secreted phosphoprotein expressed by neoplastic cells involved in the malignant potential and aggressive phenotypes of human malignancies, including gastrointestinal stromal tumors (GISTs). Our previous study showed that OPN can promote tumor cell proliferation in GISTs. In this series, we further aim to investigate the effect of OPN on apoptosis in GISTs. ME...

The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits C2-ceramide-induced cell death through blockade of the mitochondrial apoptotic pathway in rat cerebellar granule neurones. However, the gene induction processes and transcription factors involved in the anti-apoptotic effect of PACAP remain unknown. Here, we show that PACAP and C2-ceramide activate activator pr...

Plant extracts and compounds are applied to a wide variety of diseases in which traditional drugs have proven ineffective. A quickly developing trend in biomedicine is the therapeutic use of siRNA (short interfering RNA) structures. The focus of this study was on evaluating the gene expression involved in the modulation of apoptosis, in cases of combinatorial treatment (-)-epigallocatechin-3-ga...